Abstract
The form and pattern of first-order and transsynaptic degeneration in the central auditory pathway was studied in monkeys following inner ear stimulation by a cochlear implant. Multielectrode, scala tympani, and modiolar systems were implanted; in some cases, neomycin was perfused into the cochlea to destroy the organ of Corti at the time of implantation. The monkeys were maintained chronically for 5 to 120 weeks, then the cochleas and brainstems were examined histologically. The extent of spiral ganglion cell loss across animals showed variability, reflecting the different procedures and devices used. The degree and distribution of spiral ganglion cell loss was related to the degree and distribution of neural degeneration seen in the cochlear nucleus in all cases. Peripheral damage progressed toward the cochlear apex as survival time increased, and this progression was reflected in the cochlear nucleus by a ventrolateral shift in the locus of degeneration over time. In addition, evidence for transneuronal degeneration was seen at the superior olive, the lateral lemniscus and the inferior colliculus. Our findings indicate that several factors inherent in the use of a cochlear prosthesis, i.e., insertion trauma, host reaction, a...Continue Reading
References
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J R Rasmussen, J L Strominger
Jun 1, 1974·The Journal of Comparative Neurology·J R BrawerE C Kane
Apr 1, 1967·Brain Research·R P Fink, L Heimer
Mar 1, 1972·The Journal of Comparative Neurology·N Moskowitz, J C Liu
Mar 1, 1974·The Annals of Otology, Rhinology, and Laryngology·R A Schindler, M M Merzenich
Oct 1, 1969·The Annals of Otology, Rhinology, and Laryngology·W C StebbinsJ E Hawkins
Feb 1, 1969·Acta Oto-laryngologica·K K Osen
Aug 1, 1969·The Journal of Comparative Neurology·K K Osen
Feb 1, 1967·The Laryngoscope·F B Simmons
Mar 1, 1984·Archives of Otolaryngology·B E Pfingst
Jan 1, 1983·Annals of the New York Academy of Sciences·P A Leake-Jones, S J Rebscher
Jan 1, 1983·Annals of the New York Academy of Sciences·B E Pfingst, D Sutton
Apr 1, 1980·The Journal of Laryngology and Otology·J M Miller, D Sutton
Oct 1, 1980·The Journal of Comparative Neurology·J K Moore
Apr 1, 1982·Neuroscience·S Jhaveri, D K Morest
Mar 1, 1961·Transactions - American Academy of Ophthalmology and Otolaryngology·T M MCGEE
Citations
Jun 1, 1990·Brain Research. Developmental Brain Research·D R Moore
Dec 1, 1989·Hearing Research·D CairdR Klinke
Jun 1, 1993·Hearing Research·D R Moore
Dec 22, 2000·Hearing Research·A L Miller
Aug 25, 2001·Hearing Research·M TykocinskiR S Cowan
Jan 1, 1997·Hearing Research·D K MorestB A Bohne
Jan 1, 1997·Hearing Research·J KimB A Bohne
Sep 16, 2008·Cochlear Implants International·Michael Tykocinski, Robert S C Cowan
Dec 17, 1997·Experimental Neurology·S J PotashnerC G Benson
Jul 23, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H StaeckerT R Van De Water