Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery

Journal of Controlled Release : Official Journal of the Controlled Release Society
Saira AlliJames T Rutka

Abstract

Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve transient blood brain barrier (BBB) opening without tissue injury. Delivery of a targeted ultrasonic wave causes an interaction between administered microbubbles and the capillary bed resulting in enhanced vessel permeability. The use of MRgFUS in the brainstem has not previously been shown but could provide value in the treatment of tumours such as Diffuse Intrinsic Pontine Glioma (DIPG) where the intact BBB has contributed to the limited success of chemotherapy. Our primary objective was to determine whether the use of MRgFUS in this eloquent brain region could be performed without histological injury and functional deficits. Our secondary objective was to select an effective chemotherapeutic against patient derived DIPG cell lines and demonstrate enhanced brainstem delivery when combined with MRgFUS in vivo. Female Sprague Dawley rats were randomised to one of four groups: 1) Microbubble administration but no MRgFUS treatment; 2) MRgFUS only; 3) MRgFUS + microbubbles; and 4) MRgFUS + microbubbles + cisplatin. Physiological assessment was performed by monitoring of heart and respiratory rates. Motor function and co-ordination were evaluated b...Continue Reading

References

Mar 1, 1982·Neurosurgery·J S Kroin, R D Penn
Nov 7, 1999·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C R Freeman, G Perilongo
May 28, 2002·Physics in Medicine and Biology·G T Clement, K Hynynen
Apr 15, 2004·Neurobiology of Learning and Memory·Manuel M BuitragoAndreas R Luft
Nov 16, 2005·Ultrasound in Medicine & Biology·Nathan McDannoldKullervo Hynynen
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah S DonaldsonPaul Graham Fisher
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Manabu KinoshitaKullervo Hynynen
Jun 3, 2010·IEEE Transactions on Bio-medical Engineering·Meaghan A O'Reilly, Kullervo Hynynen
Sep 21, 2010·Journal of Molecular Neuroscience : MN·Xiuli ShangYixue Xue
Sep 20, 2011·Ultrasound in Medicine & Biology·Meaghan A O'ReillyKullervo Hynynen
Jan 31, 2012·Nature Genetics·Gang WuUNKNOWN St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project
Dec 18, 2012·Journal of Neurosurgery. Pediatrics·Richard C E AndersonJeffrey N Bruce
Jan 11, 2013·Cancer Research·Ryan AlkinsKullervo Hynynen
Apr 8, 2014·Nature Genetics·Adam M FontebassoMark W Kieran
Apr 8, 2014·Nature Genetics·Kathryn R TaylorJacques Grill
May 23, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nir LipsmanAndres M Lozano
May 6, 2015·Expert Review of Neurotherapeutics·Alison BurgessKullervo Hynynen
May 6, 2015·Nature Medicine·Catherine S GrassoMichelle Monje
Nov 12, 2015·Frontiers in Oncology·Magimairajan Issai Vanan, David D Eisenstat
Dec 1, 2015·Journal of Neuroscience Methods·Owen LewisSam Evans
Oct 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Juyoung ParkNathan McDannold
Dec 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Zsofia I KovacsJoseph A Frank

❮ Previous
Next ❯

Citations

Jun 17, 2020·Expert Review of Neurotherapeutics·James Felker, Alberto Broniscer
Jul 22, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying MengNir Lipsman
May 12, 2020·World Neurosurgery·Victor M LuDavid J Daniels
Dec 31, 2020·Pharmaceutics·Sheng-Kai WuKullervo Hynynen
Oct 28, 2020·Nature Reviews. Neurology·Ying MengNir Lipsman
Nov 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joji IshidaJames Rutka
Sep 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dezhuang YeHong Chen
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gi Doo ChaDae-Hyeong Kim
Dec 12, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jean-Michel Escoffre, Ayache Bouakaz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.