Brainstem circuitry regulating phasic activation of trigeminal motoneurons during REM sleep.

PloS One
Christelle AnacletJun Lu

Abstract

Rapid eye movement sleep (REMS) is characterized by activation of the cortical and hippocampal electroencephalogram (EEG) and atonia of non-respiratory muscles with superimposed phasic activity or twitching, particularly of cranial muscles such as those of the eye, tongue, face and jaw. While phasic activity is a characteristic feature of REMS, the neural substrates driving this activity remain unresolved. Here we investigated the neural circuits underlying masseter (jaw) phasic activity during REMS. The trigeminal motor nucleus (Mo5), which controls masseter motor function, receives glutamatergic inputs mainly from the parvocellular reticular formation (PCRt), but also from the adjacent paramedian reticular area (PMnR). On the other hand, the Mo5 and PCRt do not receive direct input from the sublaterodorsal (SLD) nucleus, a brainstem region critical for REMS atonia of postural muscles. We hypothesized that the PCRt-PMnR, but not the SLD, regulates masseter phasic activity during REMS. To test our hypothesis, we measured masseter electromyogram (EMG), neck muscle EMG, electrooculogram (EOG) and EEG in rats with cell-body specific lesions of the SLD, PMnR, and PCRt. Bilateral lesions of the PMnR and rostral PCRt (rPCRt), but not...Continue Reading

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Citations

Aug 19, 2014·Nature Neuroscience·Christelle AnacletPatrick M Fuller
Apr 24, 2012·Progress in Neurobiology·Birendra Nath MallickMudasir Ahmad Khanday
Jun 8, 2011·The European Journal of Neuroscience·Alvaro Sánchez-López, Miguel Escudero
Jul 19, 2015·Neuroscience Research·Keisuke KatayamaTomio Inoue
Jan 16, 2015·Journal of Sleep Research·Álvaro Sánchez-López, Miguel Escudero
Mar 23, 2013·Current Opinion in Neurobiology·Michael C ChenJun Lu
Jul 20, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christelle AnacletPatrick M Fuller
Sep 27, 2013·Journal of Neurophysiology·Jessica M D'AmicoKemal S Türker
Aug 17, 2019·Frontiers in Neuroscience·Evelyn T M EricksonChristelle Anaclet
Jun 19, 2021·Progress in Neurobiology·Yi-Qun WangZhi-Li Huang

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Methods Mentioned

BETA
X-ray

Software Mentioned

OX
SleepSign for Animal
SleepSign for
SAP
SleepSign
for Animal

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