Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study

Brain : a Journal of Neurology
Laura GuerriniMario Mascalchi

Abstract

Magnetic resonance (MR) techniques enable in vivo measurement of the atrophy of the brainstem and cerebellum in spinocerebellar ataxia type 1 (SCA1) and 2 (SCA2) patients, which is accompanied by a decrease in the concentration of N-acetyl aspartate (NAA) or of the NAA/creatine ratio in the pons and cerebellum. Mean diffusivity (D) is emerging as an additional sensitive and quantitative MR parameter to investigate brain diseases. In order to explore differences between the MR features of SCA1 and SCA2 and correlate the MR and clinical findings in the two conditions, we examined 16 SCA1 patients, 12 SCA2 patients and 20 healthy control subjects. The MR protocol included T1-weighted 3D gradient echo sequences, single-voxel proton spectroscopy of the right cerebellar hemisphere (dentate and peridentate region) and of the pons with a PRESS sequence and an external reference quantitation method, and (in nine patients with SCA1 and nine patients with SCA2) diffusion-weighted echo-planar images with reconstruction of the D maps. The patients were evaluated with the Inherited Ataxia Clinical Rating Scale (IACRS). Compared with control subjects, the SCA1 and SCA2 patients showed a decrease (P < 0.01) in the volume of the brainstem and c...Continue Reading

Citations

Oct 23, 2008·Surgical and Radiologic Anatomy : SRA·Nuket Gocmen-MasBunyamin Sahin
Apr 29, 2008·Journal of Neurology·Andrea GinestroniMario Mascalchi
Apr 18, 2008·The Cerebellum·Susanne DöhlingerJörg B Schulz
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R Grant SteenJeffrey A Lieberman
Oct 3, 2013·The Cerebellum·Sarah DossJan Leo Rinnenthal
Dec 29, 2013·AJNR. American Journal of Neuroradiology·N Tirada, L M Levy
Nov 14, 2007·AJNR. American Journal of Neuroradiology·M L MandelliM Grisoli
May 7, 2011·Revue neurologique·C MarelliA Dürr
Feb 21, 2013·Brain : a Journal of Neurology·Kathrin ReetzUNKNOWN axia Study Group Investigators
Oct 7, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B BrandauerD Timmann
May 17, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Anelyssa D'AbreuFernando Cendes
Mar 4, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Riccardo Della NaveMario Mascalchi
Feb 28, 2007·Journal of Magnetic Resonance Imaging : JMRI·Sylvia M BoeschMichael Schocke
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Alessandro BrussinoAlfredo Brusco
Jan 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Elena SalvatoreSabina Pappatà
Mar 24, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Gülin OzChristopher M Gomez
Mar 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Isaac M AdanyeguhFanny Mochel
Jun 21, 2005·Brain Research·Martin ViauYvan Boulanger
May 2, 2014·Journal of Neurology·Naohisa UedaFumiaki Tanaka
Jun 23, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Sirio CocozzaMario Quarantelli
Oct 14, 2014·BioMed Research International·Jonasz Jeremiasz WeberJeannette Hübener
May 5, 2009·Neuroscience·D TimmannB Schoch
May 5, 2016·Parkinsonism & Related Disorders·Barbara BorroniLoredana Boccone
Aug 12, 2015·PloS One·Carlos R Hernandez-CastilloJuan Fernandez-Ruiz
Jun 1, 2011·Arquivos de neuro-psiquiatria·Sarah Teixeira CamargosAntonio Carlos dos Santos
Sep 20, 2018·Arquivos de neuro-psiquiatria·Carlos Roberto Martins JuniorMarcondes Cavalcante França Júnior
Feb 19, 2016·Journal of the International Neuropsychological Society : JINS·Carlos R Hernandez-CastilloJuan Fernandez-Ruiz
Feb 9, 2020·International Journal of Molecular Sciences·Mario Mascalchi, Alessandra Vella
Oct 3, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Haitao LiXiaoning Zhang
Jan 25, 2017·Biostatistics·Tianmeng LyuLynn E Eberly
Sep 15, 2017·Annals of Clinical and Translational Neurology·Antonella AntenoraAlessandro Filla
Feb 23, 2018·Annals of Clinical and Translational Neurology·Kathrin ReetzLuis Velázquez-Pérez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.