Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity

Scientific Reports
Simon LuiJohn Peever

Abstract

The respiratory control system is plastic. It has a working memory and is capable of retaining how respiratory stimuli affect breathing by regulating synaptic strength between respiratory neurons. For example, repeated airway obstructions trigger a form of respiratory plasticity that strengthens inspiratory activity of hypoglossal (XII) motoneurons. This form of respiratory plasticity is known as long-term facilitation (LTF) and requires noradrenaline released onto XII motoneurons. However, the brainstem regions responsible for this form of LTF remain unidentified. Here, we used electrophysiology, neuropharmacology and immunohistochemistry in adult rats to identify the brainstem regions involved in mediating LTF. First, we show that repeated airway obstructions induce LTF of XII motoneuron activity and that inactivation of the noradrenergic system prevents LTF. Second, we show that noradrenergic cells in the locus coeruleus (LC), which project to XII motoneurons, are recruited during LTF induction. Third, we show that targeted inactivation of noradrenergic LC cells during LTF induction prevents LTF. And lastly, we show that the nucleus tractus solitarius (NTS), which has known projections to the LC, is critical for LTF because ...Continue Reading

References

Jan 1, 1991·Progress in Brain Research·S J FungC D Barnes
May 1, 1983·The American Review of Respiratory Disease·M H Sanders, S E Moore
Nov 1, 1982·The Journal of Comparative Neurology·M Kalia, J M Sullivan
Aug 1, 1996·Respiration Physiology·M A HaxhiuN S Cherniack
Nov 22, 1997·The Journal of Comparative Neurology·L J TeppemaC Olievier
Jul 3, 1999·Neuroscience·M F WuJ M Siegel
Sep 7, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R KinkeadG S Mitchell
Dec 12, 2001·Respiration Physiology·M A HaxhiuS O Mack
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shigeo WatanabeDaniel Johnston
Dec 23, 2003·The Journal of Comparative Neurology·Fabrice RodaChristian Gestreau
May 12, 2006·Nature·Jun LuClifford B Saper
Aug 26, 2006·American Journal of Respiratory and Critical Care Medicine·Erin ChanRichard L Horner
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Natalia V NeverovaJack L Feldman
Jul 2, 2008·Annals of the New York Academy of Sciences·Ronald Szymusiak, Dennis McGinty
Jul 16, 2008·Respiratory Physiology & Neurobiology·Richard L Horner
Apr 30, 2010·The International Journal of Neuropsychopharmacology·Cristina MiguelezLuisa Ugedo
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arash TadjalliJohn Peever
Dec 30, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·João H Costa-SilvaBenedito H Machado
Sep 3, 2013·Current Biology : CB·Christian R Burgess, John H Peever
Dec 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenta YamamotoSteve Mifflin
May 29, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J DevinneyGordon S Mitchell
Jun 18, 2017·Journal of Applied Physiology·Naomi L DeaconPeter G Catcheside
Jul 14, 2017·Frontiers in Cellular Neuroscience·Daniela GandolfiEgidio D'Angelo

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Citations

Nov 2, 2019·Experimental Physiology·Karolyne S MagalhãesDavi J A Moraes
Apr 6, 2019·Journal of Neurosurgery·William P NobisStephan Schuele

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