Brainstem serotonergic deficiency in sudden infant death syndrome.

JAMA : the Journal of the American Medical Association
Jhodie R DuncanHannah C Kinney

Abstract

Sudden infant death syndrome (SIDS) is postulated to result from abnormalities in brainstem control of autonomic function and breathing during a critical developmental period. Abnormalities of serotonin (5-hydroxytryptamine [5-HT]) receptor binding in regions of the medulla oblongata involved in this control have been reported in infants dying from SIDS. To test the hypothesis that 5-HT receptor abnormalities in infants dying from SIDS are associated with decreased tissue levels of 5-HT, its key biosynthetic enzyme (tryptophan hydroxylase [TPH2]), or both. Autopsy study conducted to analyze levels of 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA); levels of TPH2; and 5-HT(1A) receptor binding. The data set was accrued between 2004 and 2008 and consisted of 41 infants dying from SIDS (cases), 7 infants with acute death from known causes (controls), and 5 hospitalized infants with chronic hypoxia-ischemia. Serotonin and metabolite tissue levels in the raphé obscurus and paragigantocellularis lateralis (PGCL); TPH2 levels in the raphé obscurus; and 5-HT(1A) binding density in 5 medullary nuclei that contain 5-HT neurons and 5 medullary nuclei that receive 5-HT projections. Serotonin levels were 26% lower in SIDS case...Continue Reading

References

Nov 25, 1997·Journal of Neuropathology and Experimental Neurology·A PanigrahyH C Kinney
Feb 26, 2004·Paediatric Respiratory Reviews·Christian F Poets
Dec 23, 2004·Archives of Disease in Childhood·C E Hunt
Aug 18, 2005·Journal of Neuropathology and Experimental Neurology·Hannah C KinneyWilliam P Fifer
Nov 2, 2006·JAMA : the Journal of the American Medical Association·David S PatersonHannah C Kinney
Jan 24, 2007·Autonomic Neuroscience : Basic & Clinical·Hannah C KinneyDavid S Paterson
Mar 7, 2007·American Journal of Medical Genetics. Part a·Debra E Weese-MayerElizabeth M Berry-Kravis
Nov 6, 2007·Lancet·Rachel Y MoonFern R Hauck
Feb 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eugene Nattie
Apr 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin J CummingsEugene E Nattie
Apr 30, 2009·Annual Review of Pathology·Hannah C KinneyEugene E Nattie
Jun 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Natalia AleninaMichael Bader
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew R HodgesGeorge B Richerson
Aug 21, 2009·The New England Journal of Medicine·Hannah C Kinney, Bradley T Thach

❮ Previous
Next ❯

Citations

Apr 23, 2014·Nature Reviews. Neurology·Cory A MasseyGeorge B Richerson
Jun 26, 2014·Pediatric Research·Nathan Salomonis
May 31, 2014·Respiratory Physiology & Neurobiology·Bryan P MosherMichael B Harris
Oct 12, 2014·Paediatric Respiratory Reviews·Rita Machaalani, Karen A Waters
Oct 15, 2014·Sleep Medicine·Sanjeev V Kothare, Kanwaljit Singh
Apr 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin J CummingsEugene E Nattie
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gordon F Buchanan, George B Richerson
Oct 23, 2010·Journal of Applied Physiology·Eliana M PenattiEugene E Nattie
Dec 28, 2010·Brain : a Journal of Neurology·Jan-Marino Ramirez
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seth D DepuyPatrice G Guyenet
Jul 14, 2010·Forensic Science, Medicine, and Pathology·Siri H Opdal, Torleiv O Rognum
Sep 4, 2012·Forensic Science, Medicine, and Pathology·Hannah C KinneyRoger W Byard
Oct 26, 2012·Pediatric Research·Kevin J CummingsEugene E Nattie
Dec 17, 2014·Fiziologiia cheloveka·I A Kel'manson
Apr 5, 2012·Neurology Research International·Kathryn M BullerHanna E Reinebrant
Apr 14, 2011·The Journal of Physiology·Kevin J CummingsEugene E Nattie
Oct 19, 2011·The Journal of Physiology·Robert T R Huckstepp, Nicholas Dale
Sep 25, 2015·The Journal of Comparative Neurology·Hamza Numan GokozanJosé J Otero
Apr 24, 2013·Respiratory Physiology & Neurobiology·Patrice G Guyenet, Stephen B G Abbott
Feb 9, 2013·The Journal of Pediatrics·Cornelius CourtsBurkhard Madea
Dec 16, 2010·Journal of Neuropathology and Experimental Neurology·Julie A WixeyKathryn M Buller
Sep 23, 2011·Journal of Neuropathology and Experimental Neurology·Gang XuHannah C Kinney
Jan 16, 2014·Journal of Neuropathology and Experimental Neurology·Ingvar J RognumHannah C Kinney
Jan 10, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Silvia MianoMaria Pia Villa
Aug 6, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E Briand-Huchet
Feb 22, 2011·Respiratory Physiology & Neurobiology·Eliana PenattiEugene Nattie
Aug 31, 2010·Respiratory Physiology & Neurobiology·Gérard HilaireMathias Dutschmann
Nov 27, 2010·Paediatric Respiratory Reviews·John L Carroll, Amit Agarwal
Nov 10, 2015·Neuron·Benjamin W OkatySusan M Dymecki
Aug 26, 2011·Journal of Neuropathology and Experimental Neurology·Kevin G BroadbeltHannah C Kinney
Nov 14, 2012·Journal of Neuropathology and Experimental Neurology·Julie A WixeyKathryn M Buller
Dec 15, 2015·Brain Structure & Function·Liang YangChi-Sang Poon
Sep 22, 2015·Journal of the Neurological Sciences·David T Mage, E Maria Donner
Jan 14, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Guo-Lin Chen, Gregory M Miller
Jan 19, 2011·Epilepsia·George B Richerson, Gordon F Buchanan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

JAMA : the Journal of the American Medical Association
David S PatersonHannah C Kinney
Annual Review of Pathology
Hannah C KinneyEugene E Nattie
Respiratory Physiology & Neurobiology
David S PatersonDebra E Weese-Mayer
The New England Journal of Medicine
Hannah C Kinney, Bradley T Thach
© 2021 Meta ULC. All rights reserved