Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C-H Oxidative Addition.

Journal of the American Chemical Society
Simon GrélaudJohn F Bower

Abstract

Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C-H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.

References

Apr 22, 2003·Chemical Communications : Chem Comm·Romano Dorta, Antonio Togni
Jun 5, 2004·The Journal of Organic Chemistry·Christopher J CobleyKhalil A Abboud
Oct 28, 2004·Journal of the American Chemical Society·Clément MazetAndreas Pfaltz
Mar 24, 2009·Journal of the American Chemical Society·Daisuke ImaoCathleen M Crudden
Nov 17, 2010·Journal of the American Chemical Society·Deidre L SandrockGary A Molander
Dec 16, 2010·Journal of the American Chemical Society·Buck L H TaylorElizabeth R Jarvo
Jan 26, 2013·Journal of the American Chemical Society·Christo S Sevov, John F Hartwig
May 3, 2013·Journal of the American Chemical Society·Alan H CherneySarah E Reisman
Jun 21, 2014·Nature Chemistry·Amadeu BonetVarinder K Aggarwal
Jul 16, 2014·Journal of the American Chemical Society·Giacomo E M CrisenzaJohn F Bower
Sep 17, 2014·Journal of the American Chemical Society·Ling LiMark R Biscoe
Nov 22, 2014·Angewandte Chemie·Daniele Leonori, Varinder K Aggarwal
Dec 17, 2014·Organic Letters·Pin-Sheng Lee, Naohiko Yoshikai
Dec 30, 2014·Journal of the American Chemical Society·Claire M Filloux, Tomislav Rovis
Aug 22, 2015·Journal of the American Chemical Society·Josep LlaveriaVarinder K Aggarwal
Jun 28, 2016·Journal of the American Chemical Society·Stig D FriisStephen L Buchwald
Jul 8, 2016·Journal of the American Chemical Society·Marcin OdachowskiVarinder K Aggarwal
Aug 30, 2016·Journal of the American Chemical Society·Zhi-Min ChenMatthew S Sigman
Oct 28, 2016·Chemistry : a European Journal·Takanori ShibataKyalo Stephen Kanyiva
Jan 27, 2017·Chemical Reviews·Zhe DongGuangbin Dong
Feb 18, 2017·Chemical Communications : Chem Comm·Daisuke YamauchiHideki Yorimitsu
Apr 14, 2017·Journal of the American Chemical Society·Kelsey E PorembaSarah E Reisman
May 20, 2017·Angewandte Chemie·Beatrice S L CollinsVarinder K Aggarwal
Jul 1, 2017·Journal of the American Chemical Society·James R SmithVarinder K Aggarwal
Sep 19, 2017·Angewandte Chemie·Joachim LoupLutz Ackermann
Nov 18, 2017·Journal of the American Chemical Society·Jason P G Rygus, Cathleen M Crudden
Apr 4, 2018·Journal of the American Chemical Society·Michael W GribbleStephen L Buchwald

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Citations

Sep 2, 2018·Angewandte Chemie·Phillippa CooperJohn F Bower
Oct 24, 2018·Chemical Communications : Chem Comm·Guanyinsheng QiuJie Wu
Aug 15, 2018·Angewandte Chemie·Gwilherm Evano, Cédric Theunissen
Feb 2, 2019·Angewandte Chemie·Dong XingGuangbin Dong
Jul 30, 2019·Chemical Communications : Chem Comm·Liangyao XuGuofu Zhong
Nov 12, 2020·Chemical Communications : Chem Comm·Yuan NiuShangdong Yang
Jun 9, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Takahiro Nishimura
Jun 22, 2021·Journal of the American Chemical Society·Chen-Fei LiuMing Joo Koh
Jun 30, 2021·Chemical Communications : Chem Comm·En-Kai XiaoPeng Chen
May 27, 2021·Chemistry : a European Journal·Karunanidhi MuraliDebabrata Maiti
Feb 12, 2019·Journal of the American Chemical Society·Yue-Gang ChenTian-Sheng Mei
May 8, 2020·Journal of the American Chemical Society·Alena M VasquezKeary M Engle
Sep 9, 2020·Chemical Reviews·Łukasz WoźniakNicolai Cramer
Nov 5, 2020·Organic Letters·Qi Cheng, Yanfeng Dang
May 8, 2019·Journal of the American Chemical Society·C Rose KennedyPaul J Chirik
Jan 6, 2021·Journal of the American Chemical Society·Pinglu ZhangBenjamin List
Sep 23, 2020·The Journal of Organic Chemistry·Fen Wang, Qingxi Meng
Nov 9, 2021·Journal of the American Chemical Society·Yan-Hua LiuBing-Feng Shi
Dec 3, 2021·The Journal of Organic Chemistry·Gongming PengFrançois Jérôme
Dec 7, 2021·Journal of the American Chemical Society·Harvey J A DaleGuy C Lloyd-Jones

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