Branched and linear lipopeptide vaccines have different effects on primary CD4+ and CD8+ T-cell activation but induce similar tumor-protective memory CD8+ T-cell responses

Vaccine
Adriana BazAnne Kelso

Abstract

We compared murine T-cell responses to synthetic lipopeptide vaccines in which the TLR2 ligand Pam(2)Cys was attached to co-linear CD4+ and CD8+ T-cell epitopes of ovalbumin (OVA) in a linear or branched configuration. Mice received OVA-specific transgenic CD8+ and CD4+ T-cells followed by one injection of vaccine. Although the branched lipopeptide was more potent in activating OVA-specific CD4+ and CD8+ T-cells in the primary response, both vaccines induced cytolytic T lymphocytes (CTL) that expressed perforin, granzyme A-C, and IFN-gamma mRNAs and conferred long-term protection of most mice against challenge with OVA-expressing tumor cells. OVA epitope display was reduced in tumors that developed in some mice, suggesting CD8+ T-cell dependent selection.

References

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Citations

Apr 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kuan-Yin ShenShih-Jen Liu
Jul 25, 2014·Journal of Immunology Research·Afonso P Basto, Alexandre Leitão
Jan 22, 2010·Amino Acids·Weiguang ZengDavid C Jackson
Jan 23, 2016·European Journal of Immunology·Adriana BazAnne Kelso
Nov 9, 2010·Molecular Immunology·Weiguang ZengDavid C Jackson
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicole BrooksGeoffrey A Pietersz
Jun 16, 2021·Genome Medicine·Christof C SmithAlex Rubinsteyn

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