PMID: 3767484Nov 1, 1986Paper

Branched chain amino acid uptake and muscle free amino acid concentrations predict postoperative muscle nitrogen balance

Annals of Surgery
D J JohnsonD W Wilmore

Abstract

Amino acid solutions rich in branched chain amino acids (BCAA) are commonly utilized both clinically and in experimental protocols in an attempt to reduce skeletal muscle and whole body protein catabolism. To investigate the effectiveness of BCAA infusion, amino acid formulas containing varying concentrations of BCAA were given during operation in this study to three groups of dogs undergoing a standard laparotomy and retroperitoneal dissection. A fourth group was given saline alone. With the use of previously described hindquarter flux techniques, individual and total amino acid nitrogen exchange rates were measured and utilized in estimating skeletal muscle protein catabolism. Intracellular free amino acid concentrations were measured in percutaneous muscle biopsy samples. Although there was no relationship with the rate of BCAA infusion, there was a significant correlation between the rate of BCAA uptake by muscle and diminished total nitrogen release from hindquarter skeletal muscle after operation. There was also a significant relationship between muscle nitrogen balance and the postoperative change in the muscle concentration of either total amino acids or the single amino acid glutamine. When combined in a single equatio...Continue Reading

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Citations

Jul 1, 1989·World Journal of Surgery·P Q BesseyD W Wilmore
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·P B SoetersN E Deutz
Aug 11, 2000·Journal of Gastroenterology and Hepatology·C PlatellJ C Hall
Oct 1, 1993·Annals of Surgery·P Q Bessey, K A Lowe
Oct 1, 1994·Australian Veterinary Journal·S Donoghue
Feb 1, 1989·Chest·B ChernowA L Warshaw
Jul 13, 2002·The Surgical Clinics of North America·L R Scherer
Jan 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·P J ArmstrongG S Frederick
May 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·S Donoghue
Jan 1, 1988·The Journal of Surgical Research·V BakicF W Booth
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·R J Smith, D W Wilmore
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·R J Smith
Jul 22, 2004·American Journal of Physiology. Endocrinology and Metabolism·Dominic S C RajArny Ferrando
Jun 1, 1990·The Australian and New Zealand Journal of Surgery·R McCauleyR McCulloch
Jan 1, 1991·The Australian and New Zealand Journal of Surgery·R McCauleyJ Hall
Apr 1, 1990·Journal of the American College of Nutrition·D J ScholtenR M Albrecht
Aug 1, 1990·Nutrition Reviews·J M Lacey, D W Wilmore
Jan 6, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel A MurphyUNKNOWN Health ABC Study
Dec 21, 2005·The Journal of Nutrition·Haroon A ChoudryWiley W Souba

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