Branched-chain amino acids and neurotransmitter metabolism: expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus

The Journal of Comparative Neurology
Andrew J SweattS M Hutson

Abstract

In the brain, catabolism of the branched-chain amino acids (BCAAs) provides nitrogen for the synthesis of glutamate and glutamine. Glutamate is formed through transfer of an amino group from BCAA to alpha-ketoglutarate in reaction catalyzed by branched-chain aminotransferases (BCAT). There are two isozymes of BCAT: cytosolic BCATc, which is found in the nervous system, ovary, and placenta, and mitochondrial BCATm, which is found in all organs except rat liver. In cell culture systems, BCATc is found only in neurons and developing oligodendrocytes, whereas BCATm is the isoform in astroglia. In this study, we used immunohistochemistry to examine the distribution of BCATc in the rat brain, focusing on the well-known neural architecture of the cerebellum and hippocampus. We show that BCATc is expressed only in neurons in the adult rat brain. In glutamatergic neurons such as granule cells of the cerebellar cortex and of the dentate gyrus, BCATc is localized to axons and nerve terminals. In contrast, in GABAergic neurons such as cerebellar Purkinje cells and hippocampal pyramidal basket cells, BCATc is concentrated in cell bodies. A common function for BCATc in these neurotransmitter systems may be to modulate amounts of glutamate av...Continue Reading

References

Apr 1, 1976·Journal of Neurochemistry·E R ChaplinI Diamond
Apr 1, 1987·Physiological Reviews·A J Cooper, F Plum
Nov 1, 1987·Journal of Neurochemistry·Q R SmithS I Rapoport
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Aug 30, 1983·Biochemical and Biophysical Research Communications·M YudkoffS Segal
Dec 22, 1995·The Journal of Biological Chemistry·S M HutsonP A Dawson
Nov 1, 1995·The Annals of Pharmacotherapy·D F WeltyJ D Rothstein
May 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M G BixelB Hamprecht
Mar 7, 1998·Journal of Neurochemistry·K KanamoriR W Kondrat
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Jan 1, 1999·Trends in Pharmacological Sciences·J J Soghomonian, D L Martin
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A ReichelN J Abbott
Mar 29, 2000·The Journal of Nutrition·Y Daikhin, M Yudkoff
Feb 22, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M BixelB Hamprecht
Mar 22, 2001·Journal of Neurochemistry·E LiethS M Hutson
Dec 18, 2001·Journal of Neuroscience Research·K F LaNoueS Hutson
May 22, 2002·Molecular Pharmacology·Anders A JensenHans Bräuner-Osborne
Jul 18, 2002·Epilepsia·Matthew C WalkerDimitri M Kullmann
Oct 22, 2002·Expert Opinion on Pharmacotherapy·Nanna B FinnerupTroels S Jensen
Nov 28, 2002·The Journal of Comparative Neurology·Fahad SultanPeter Thier
Mar 18, 2003·Journal of Clinical Psychopharmacology·Carrie L Ernst, Joseph F Goldberg
Jul 3, 2003·Hippocampus·Sandrine BertrandJean-Claude Lacaille
Jul 23, 2003·Journal of Psychopharmacology·Heather Ashton, Allan H Young
Sep 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Andrew J SweattSusan M Hutson
Oct 29, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helle S WaagepetersenArne Schousboe

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Citations

Feb 8, 2006·Amino Acids·A J L Cooper, J T Pinto
Feb 1, 2008·Journal of Inherited Metabolic Disease·Claude Bachmann
May 5, 2011·Journal of Inherited Metabolic Disease·William J Zinnanti, Jelena Lazovic
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey T ColeAkiva S Cohen
Nov 9, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shalini Saggu, Robert F Lundy
Oct 13, 2007·The Journal of Clinical Investigation·William J ZinnantiKeith C Cheng
Jan 30, 2013·International Journal of Molecular Sciences·Mohammad Shamsul OlaAbdullah S Alhomida
Feb 16, 2010·Brain Research·Alexandre Umpierrez AmaralMoacir Wajner
Mar 29, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sadia A ButtJan H Ardenkjær-Larsen
Dec 8, 2006·Gene Expression Patterns : GEP·Stefania CastellanoYuri Bozzi
Jul 22, 2010·The European Journal of Neuroscience·Manisha NautiyalSusan M Hutson
Oct 28, 2006·Seminars in Cell & Developmental Biology·Y P ManeufK Lee
Jun 17, 2006·European Journal of Pharmacology·Małgorzata FilipEdmund Przegaliński
Oct 18, 2005·Biochemical and Biophysical Research Communications·Hitomi TakanagaMatthias A Hediger
Feb 14, 2006·Journal of Pharmacological Sciences·Jen-Kun Cheng, Lih-Chu Chiou
Apr 27, 2016·Critical Reviews in Biochemistry and Molecular Biology·James Offord, Lori L Isom
Dec 15, 2015·PLoS Genetics·Joanne M KingsburyMaria E Cardenas
Jul 13, 2017·Nature Communications·Adonia E PapathanassiuJacques Behmoaras
Mar 5, 2019·Neurotoxicity Research·Mohammad Shamsul OlaKathryn F LaNoue
Feb 23, 2007·The Journal of Biological Chemistry·Mohammad Mainul IslamSusan M Hutson
Sep 6, 2018·Current Neuropharmacology·Roger Kalla, Michael Strupp
May 23, 2014·The Journal of Biological Chemistry·Elitsa A AnanievaSusan M Hutson
Feb 3, 2015·Journal of Neuroscience Research·Jonathon HullMyra E Conway
Jun 18, 2017·Molecular Neurobiology·Katalin VölgyiArpád Dobolyi
Jul 9, 2020·Antioxidants & Redox Signaling·Myra Elizabeth Conway
Apr 19, 2017·Neurochemical Research·Justin E SperringerSusan M Hutson
Jun 3, 2005·The Journal of Nutrition·Susan M HutsonKathryn F Lanoue
Feb 13, 2020·Biogerontology·Myra E Conway
Aug 28, 2007·Neurochemical Research·Radovan Murín, Bernd Hamprecht

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