Branched-chain amino acids for people with hepatic encephalopathy

The Cochrane Database of Systematic Reviews
Lise L GluudHendrik Vilstrup

Abstract

Hepatic encephalopathy is a brain dysfunction with neurological and psychiatric changes associated with liver insufficiency or portal-systemic shunting. The severity ranges from minor symptoms to coma. A Cochrane systematic review including 11 randomised clinical trials on branched-chain amino acids (BCAA) versus control interventions has evaluated if BCAA may benefit people with hepatic encephalopathy. To evaluate the beneficial and harmful effects of BCAA versus any control intervention for people with hepatic encephalopathy. We identified trials through manual and electronic searches in The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Science Citation Index Expanded and Conference Proceedings Citation Index - Science, and LILACS (May 2017). We included randomised clinical trials, irrespective of the bias control, language, or publication status. The authors independently extracted data based on published reports and collected data from the primary investigators. We changed our primary outcomes in this update of the review to include mortality (all cause), hepatic encephalopathy (number of people without improved manifestations of hepa...Continue Reading

Associated Clinical Trials

Sep 15, 2017·Jose Miguel Arbones Mainar

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Citations

Oct 14, 2017·F1000Research·Victoria LiereSharon DeMorrow
Jan 6, 2019·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalCristina Elena Martí-Amarista
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Aug 28, 2019·Clinical Nutrition ESPEN·João VasquesHelena Cortez-Pinto

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