Abstract
Branched chain amino acids (BCAAs) are involved in various bioprocess such as protein metabolism, gene expression, insulin resistance and proliferation of hepatocytes. BCAAs have also been reported to suppress the growth of hepatocellular carcinoma (HCC) cells in vitro and to be required for immune cells to perform the function. In advanced cirrhotic patients, it has been clarified that serum concentrations of BCAA are decreased, whereas those of aromatic amino acids (AAAs) are increased. These alterations are thought to be the causes of hepatic encephalopathy (HE), sarcopenia and hepatocarcinogenesis and may be associated with the poor prognosis of patients with these conditions. Administration of BCAA-rich medicines has shown positive results in patients with cirrhosis.
Citations
Aug 14, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Xenophon TheodoridisDimitrios P Bogdanos
Oct 9, 2019·Cancers·Da Jung KimJoo-Youn Cho
May 29, 2020·Journal of the International Society of Sports Nutrition·James R KomorowskiKazim Sahin
Feb 23, 2020·Scientific Reports·Liis PohlaKülli Kingo
May 21, 2020·Nutrients·Jung Gil ParkWon Kee Lee
Dec 25, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mohammad Amin Fallahzadeh, Robert S Rahimi
Sep 22, 2020·Clinical and Translational Gastroenterology·Manu V ChakravarthyArun J Sanyal
Jul 30, 2020·Journal of Clinical Medicine·Chisato SaekiAkihito Tsubota
Sep 20, 2020·Journal of Hepato-biliary-pancreatic Sciences·Hiroyuki HachiyaKeiichi Kubota
Dec 5, 2020·Gut·Allison AgusHarry Sokol
Jul 4, 2020·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hanxu WuChang Wang
Mar 23, 2021·Gastroenterology Report·Daniel G TenenJustin L Tan
Mar 21, 2021·Nutrition·Akiko EguchiYoshiyuki Takei
Mar 20, 2021·Biotechnology and Bioengineering·Corinna SchmidtAline Zimmer
Jul 6, 2021·Acta Pharmaceutica Sinica. B·Lili DingLi Yang
Jul 22, 2021·Reviews in Endocrine & Metabolic Disorders·Carolina Gutiérrez-RepisoFrancisco J Tinahones
Apr 27, 2021·Molecular Nutrition & Food Research·Zhi Xin Yau-QiuAna María Rodríguez
Aug 29, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Akira OkadaTakashi Kadowaki
Sep 8, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Lili LiSong Qin
Oct 28, 2021·European Journal of Nutrition·Geng-Hao BaiWen-Hsuan Hou
May 22, 2020··Zhaoyang Cao, Zhaoyang Cao