Branched-chain amino acids modulate the expression of hepatic fatty acid metabolism-related genes in female broiler chickens

Molecular Nutrition & Food Research
Jie BaiSami Dridi

Abstract

The effects and roles of branched-chain amino acids (BCAAs) in hepatic fat metabolism are still unknown. Here, we used broiler chickens, in which lipogenesis occurs essentially in the liver as in human, to investigate the effects of three levels of BCAAs (control "C," low "L" and exogenous supplemented diet "L+S") on growth, carcass traits, immunity, and hepatic fat metabolism. Despite the same productive performance, immunity, and plasma BCAA levels between all groups, low BCAA levels significantly downregulated the hepatic expression of lipogenic genes particularly acetyl-CoA carboxylase alpha (ACCα) and stearoyl-coA desaturase 1 (p = 0.0036 and p = 0.0008, respectively) and upregulated the hepatic expression of mitochondrial β-oxidation- (uncoupling protein and NRF-1, p < 0.05) and dynamic-related genes (DNM1, p < 0.05). Concomitant with these changes, low BCAA levels increased the phosphorylation of AMP-activated protein kinase (AMPK)α(Thr172), ACCα(Ser79), and forkhead box protein O1 (FoxO1(Ser256)) and decreased the phosphorylation of mTOR(Ser2481) and P70 S6 kinase (Thr389). The mRNA abundance of the transcription factors SREBP1/2, peroxisome proliferator activated receptor alpha/beta, and FoxO1 were also increased in th...Continue Reading

References

Jul 1, 1978·The Journal of Nutrition·T K Smith, R E Austic
May 1, 1977·Diabetologia·J SimonG Rosselin
Sep 1, 1976·Poultry Science·W L Tuttle, S L Balloun
Jun 20, 1986·Journal of Chromatography·Z DeylM Horakova
Apr 1, 1973·Journal of Animal Science·G A OestemerR J Meade
Jun 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·G A LeveilleK Chakbabarty
Jul 1, 1967·The American Journal of Physiology·A G Goodridge, E G Ball
Jun 1, 1967·Biochemistry·A G Goodridge, E G Ball
Jun 28, 1996·Journal of Chromatography. B, Biomedical Applications·D Fekkes
Jan 1, 1997·Annual Review of Nutrition·K H Kim
Feb 12, 2000·British Poultry Science·Y AkibaK Takahashi
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·N NasrinM C Alexander-Bridges
May 29, 2002·Biochimica Et Biophysica Acta·Richard C Scarpulla
Aug 3, 2002·European Journal of Biochemistry·Ulrike KrauseLouis Hue
May 20, 2003·Nature·Pere PuigserverBruce M Spiegelman
Aug 6, 2003·General and Comparative Endocrinology·Yoshinori SekiYukio Akiba
Nov 7, 2003·Poultry Science·G N ScheuermannD R Mulvaney
Dec 20, 2003·Biochemical and Biophysical Research Communications·Céline JoussePierre Fafournoux
Feb 6, 2004·Domestic Animal Endocrinology·Joëlle DupontMohammed Taouis
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Sep 18, 2004·Circulation Research·Janice M Huss, Daniel P Kelly
Oct 26, 2005·Human Molecular Genetics·Hsiuchen Chen, David C Chan
Dec 21, 2005·The Journal of Nutrition·Phillip C Calder
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Feb 14, 2006·The American Journal of Clinical Nutrition·Scot R Kimball, Leonard S Jefferson
Mar 21, 2006·Biochemical Society Transactions·R W BrownseyW M Lee
Apr 28, 2006·British Poultry Science·S A ThorntonM T Kidd
Aug 15, 2006·The Journal of Clinical Investigation·Michihiro MatsumotoDomenico Accili
Apr 9, 2008·Oncogene·D N GrossM J Birnbaum
Apr 29, 2008·Molecular Cell·Dana M GwinnReuben J Shaw
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Jul 5, 2008·Annual Review of Nutrition·David Saggerson
Sep 4, 2008·American Journal of Physiology. Endocrinology and Metabolism·Joseph AvruchNing Dai

❮ Previous
Next ❯

Citations

Jan 28, 2017·Journal of Animal Science and Biotechnology·Shihai ZhangShiyan Qiao
Mar 24, 2018·International Journal of Molecular Sciences·Cunxi NieXi Ma
May 8, 2018·Journal of Zhejiang University. Science. B·Xing-Ting LiuCai-Qiao Zhang
Sep 15, 2018·Journal of Animal Science and Biotechnology·Marco ZampigaFederico Sirri
May 3, 2019·Journal of Animal Physiology and Animal Nutrition·Canan Kop-Bozbay, Nuh Ocak
May 28, 2020·Frontiers in Veterinary Science·Travis W TablerSami Dridi
Feb 26, 2020·Journal of Animal Science and Biotechnology·Chang MaBing Dong
Mar 27, 2021·Poultry Science·Shemil P MacellineSonia Yun Liu
Jun 11, 2021·Journal of Agricultural and Food Chemistry·Lingyu ZhangYulong Yin
Jun 22, 2020·The Science of the Total Environment·Shanlong TangHongfu Zhang
Sep 21, 2021·Critical Reviews in Food Science and Nutrition·Elżbieta SupruniukAdrian Chabowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.