Branched-chain amino acids to tyrosine ratio value as a potential prognostic factor for hepatocellular carcinoma.

World Journal of Gastroenterology : WJG
Toru Ishikawa

Abstract

The prognosis of hepatocellular carcinoma (HCC) depends on tumor extension as well as hepatic function. Hepatic functional reserve is recognized as a factor affecting survival in the treatment of HCC; the Child-Pugh classification system is the most extensively used method for assessing hepatic functional reserve in patients with chronic liver disease, using serum albumin level to achieve accurate assessment of the status of protein metabolism. However, insufficient attention has been given to the status of amino acid (AA) metabolism in chronic liver disease and HCC. Fischer's ratio is the molar ratio of branched-chain AAs (BCAAs: leucine, valine, isoleucine) to aromatic AAs (phenylalanine, tyrosine) and is important for assessing liver metabolism, hepatic functional reserve and the severity of liver dysfunction. Although this ratio is difficult to determine in clinical situations, BCAAs/tyrosine molar concentration ratio (BTR) has been proposed as a simpler substitute. BTR correlates with various liver function examinations, including markers of hepatic fibrosis, hepatic blood flow and hepatocyte function, and can thus be considered as reflecting the degree of hepatic impairment. This manuscript examines the literature to clar...Continue Reading

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Citations

Sep 13, 2012·World Journal of Gastroenterology : WJG·Toru Ishikawa
Mar 15, 2014·World Journal of Gastroenterology : WJG·Tomoaki IshiharaYoshiyuki Takei
Aug 5, 2015·International Journal of Cancer. Journal International Du Cancer·Magdalena StepienMazda Jenab
Jul 12, 2014·Chemico-biological Interactions·Yuanyuan LiWenyuan Gao
Sep 7, 2016·Food Chemistry·Nuria Martinez-SaezMaria Dolores Del Castillo
Aug 10, 2016·Journal of Proteome Research·Victor Ruiz-RodadoMartin Grootveld
May 9, 2019·Journal of Veterinary Internal Medicine·Rommaneeya Leela-ArpornMitsuyoshi Takiguchi
Aug 1, 2020·International Journal of Cancer. Journal International Du Cancer·Magdalena StepienMazda Jenab
Feb 6, 2017·British Journal of Cancer·Magdalena StepienMazda Jenab
Sep 29, 2019·Analytical Biochemistry·Moemi TatsumiToshimi Mizukoshi
Jan 6, 2021·BMC Sports Science, Medicine and Rehabilitation·Katsuhiko TsunekawaMasami Murakami
Feb 25, 2021·European Journal of Preventive Cardiology·Frank BeutnerUta Ceglarek

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