Abstract
The prognosis of hepatocellular carcinoma (HCC) depends on tumor extension as well as hepatic function. Hepatic functional reserve is recognized as a factor affecting survival in the treatment of HCC; the Child-Pugh classification system is the most extensively used method for assessing hepatic functional reserve in patients with chronic liver disease, using serum albumin level to achieve accurate assessment of the status of protein metabolism. However, insufficient attention has been given to the status of amino acid (AA) metabolism in chronic liver disease and HCC. Fischer's ratio is the molar ratio of branched-chain AAs (BCAAs: leucine, valine, isoleucine) to aromatic AAs (phenylalanine, tyrosine) and is important for assessing liver metabolism, hepatic functional reserve and the severity of liver dysfunction. Although this ratio is difficult to determine in clinical situations, BCAAs/tyrosine molar concentration ratio (BTR) has been proposed as a simpler substitute. BTR correlates with various liver function examinations, including markers of hepatic fibrosis, hepatic blood flow and hepatocyte function, and can thus be considered as reflecting the degree of hepatic impairment. This manuscript examines the literature to clar...Continue Reading
References
Oct 23, 1976·Lancet·P B Soeters, J E Fischer
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Jan 1, 1984·Nutrition and Cancer·N NagasueS Hirose
May 1, 1982·Gut·M Y MorganS Sherlock
Sep 14, 1999·Surgery Today·T NigumaJ Kodani
Jul 13, 2002·Expert Review of Anticancer Therapy·Y ShiratoriM Omata
Oct 7, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yasutoshi MutoUNKNOWN Long-Term Survival Study Group
Citations
Sep 13, 2012·World Journal of Gastroenterology : WJG·Toru Ishikawa
Mar 15, 2014·World Journal of Gastroenterology : WJG·Tomoaki IshiharaYoshiyuki Takei
Aug 5, 2015·International Journal of Cancer. Journal International Du Cancer·Magdalena StepienMazda Jenab
Nov 21, 2012·Molecular Nutrition & Food Research·Huijuan JiaHisanori Kato
Jul 12, 2014·Chemico-biological Interactions·Yuanyuan LiWenyuan Gao
Sep 7, 2016·Food Chemistry·Nuria Martinez-SaezMaria Dolores Del Castillo
Aug 10, 2016·Journal of Proteome Research·Victor Ruiz-RodadoMartin Grootveld
Jul 10, 2012·Journal of Proteome Research·Guozhu YeGuowang Xu
Jul 31, 2013·Analytical Chemistry·Shili ChenGuowang Xu
Oct 14, 2016·Scientific Reports·Guozhu YeSijun Dong
May 9, 2019·Journal of Veterinary Internal Medicine·Rommaneeya Leela-ArpornMitsuyoshi Takiguchi
Aug 23, 2019·Nutrition and Cancer·Takanori ItoMitsuhiro Fujishiro
Aug 1, 2020·International Journal of Cancer. Journal International Du Cancer·Magdalena StepienMazda Jenab
Feb 6, 2017·British Journal of Cancer·Magdalena StepienMazda Jenab
May 10, 2019·Pharmaceutical Biology·Wenlong YangBaogang Xie
May 11, 2019·Toxins·Zain ZuberiA Alia
Sep 4, 2020·BMC Medicine·Nazlisadat Seyed KhoeiHeinz Freisling
Sep 29, 2019·Analytical Biochemistry·Moemi TatsumiToshimi Mizukoshi
Dec 12, 2020·Hepatology Communications·Masashi HirookaYoichi Hiasa
Jan 6, 2021·BMC Sports Science, Medicine and Rehabilitation·Katsuhiko TsunekawaMasami Murakami
Feb 10, 2021·Biomedicines·Inês V da SilvaRita Castro
Feb 25, 2021·European Journal of Preventive Cardiology·Frank BeutnerUta Ceglarek
May 8, 2021·Cancer Medicine·Atsushi HiraokaYoichi Hiasa