PMID: 2122037Sep 1, 1990Paper

Branched-chain-enriched amino acid solutions in patients with liver failure: an early example of nutritional pharmacology

JPEN. Journal of Parenteral and Enteral Nutrition
J E Fischer

Abstract

The use of BCAA in the treatment of hepatic failure has been controversial. Even in retrospect, it is difficult to know why this controversy existed and why it has been so emotional, except for the fact that such a treatment modality has flown in the face of conventional therapy of hepatic encephalopathy, and also, probably more importantly, directly attacked some of the cherished notions of the nature of hepatic encephalopathy. Time and distance have allowed some of the controversy to die down, and as time has elapsed it has become clear that at least in the area of nutritional support of patients with hepatic failure, BCAA are the preferred alternative to treat patients who are otherwise protein intolerant. A recent unbiased review using the techniques of meta-analysis has concluded that the BCAA are efficacious for the treatment of patients with hepatic encephalopathy. Since this manuscript was completed another study has been reported. In this study, it was notable that those patients treated with oral BCAA became neurologically normal, a finding which the authors found very striking.

References

Apr 1, 1978·Metabolism: Clinical and Experimental·H M RosenJ E Fisher
Jul 1, 1990·Gastroenterology·R L Koretz
Aug 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L S Eriksson, H O Conn
Jan 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·P RigottiJ E Fischer
Jan 1, 1974·American Journal of Surgery·J E FischerF Deindoerfer
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D HorstC E Atterbury
Oct 1, 1982·Digestive Diseases and Sciences·F Rossi-FanelliG Giunchi
Oct 1, 1980·Annals of Internal Medicine·H F HerlongM Walser
Jan 1, 1982·Scandinavian Journal of Infectious Diseases·A FrydénJ Mårtensson

❮ Previous
Next ❯

Citations

Nov 14, 1997·Lancet·R Jalan, P C Hayes
Apr 13, 1999·Nutrition·B A Mizock
May 20, 1999·Chest·S ChanG L Blackburn
Aug 3, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takashi OonoIsao Sakaida
Mar 20, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kojiro MichitakaMorikazu Onji
Jun 1, 1993·Journal of the American Dietetic Association·J D McCraeL M Udine
Jul 18, 2000·The Surgical Clinics of North America·G P Dabrowski, J L Rombeau
Jan 10, 2009·International Anesthesiology Clinics·Elamin M Elamin, Enrico Camporesi
Feb 18, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Marialena MouzakiSimon C Ling
Mar 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·A FabbriG Marchesini
Oct 1, 1996·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·E G Ford
Apr 1, 1997·Journal of Gastroenterology and Hepatology·S T Fan
Aug 18, 2000·Nutrition Reviews·S D LiA Hagerty
Mar 5, 2004·Nutrition Reviews·Ranjan Mascarenhas, Sohrab Mobarhan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.