Branched-chain ketoacids reduce muscle protein degradation in Duchenne muscular dystrophy

Muscle & Nerve
P M StewartD B Drachman

Abstract

In order to determine whether branched-chain ketoacids can reduce the excessive rate of muscle protein degradation that characterizes Duchenne muscular dystrophy, nine boys affected with the disease were studied in a metabolic ward while receiving meat-free diets. After a three-day equilibration period, excretion rates of 3-methylhistidine and creatinine were measured in two consecutive four-day periods. In the second period, a supplement containing a mixture of ornithine alpha-ketoisocaproate, alpha-ketoisovalerate, and alpha-keto-beta-methylvalerate in a proportion of 4:1:1 was administered orally at a dosage of 0.45 gm/kg/day. During treatment with the ketoacids, 3-methylhistidine excretion fell by a small (mean: 14%) but highly significant (P less than 0.01) extent, whether expressed in absolute terms or in relation to creatinine excretion. No adverse effects were noted. We conclude that this mixture of ketoacids acutely reduces muscle protein degradation in patients with Duchenne muscular dystrophy.

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Citations

Jan 1, 1984·Acta Neuropathologica·G FerrièreJ Rodriguez
Oct 1, 1990·Kidney International·M Walser
Oct 11, 2005·Physical Medicine and Rehabilitation Clinics of North America·David D Kilmer, Holly H Zhao
Jan 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·M Walser
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Related Concepts

Krebiozen
Keto Acids
Methylhistidines
Muscle Proteins
Muscular Dystrophy
Nitrogen

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