Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases

Current Genetics
Katsunori Sugimoto

Abstract

Phosphatidylinositol 3-kinase-related kinases (PIKKs), are structurally related to phosphatidylinositol 3-kinase (lipid kinase), but possess protein kinase activities. PIKKs include ATM, ATR, DNA-PK, mTOR and SMG1, key regulators of cell proliferation and genome maintenance. TRRAP, which is devoid of protein kinase activity, is the sixth member of the PIKK family. PIKK family members are gigantic proteins in the range of 300-500 kDa. It has become apparent in the last decade that the stability or maturation of the PIKK family members depends on a molecular chaperone called the Tel2-Tti1-Tti2 (TTT) complex. Several lines of evidence have established a model in which TTT connects to the Hsp90 chaperone through the Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex in mammalian and yeast cells. However, recent studies of yeast cells indicate that TTT is able to form different complexes. These observations raise a possibility that several different mechanisms regulate TTT-mediated protein stability of PIKKs.

References

Jul 15, 1997·Genes & Development·Y KimuraS Lindquist
Apr 27, 2000·Trends in Biochemical Sciences·R BosottiE L Sonnhammer
Jan 30, 2003·Cell·Jason Perry, Nancy Kleckner
Apr 15, 2004·Molecular and Cellular Biology·Yoshihiko Miyata, Eisuke Nishida
Jun 11, 2004·Annual Review of Biochemistry·Agata Smogorzewska, Titia de Lange
Dec 23, 2006·Trends in Cell Biology·Avrom J CaplanMaria A Theodoraki
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Kenneth K Lee, Jerry L Workman
Dec 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takeshi HayashiMitsuhiro Yanagida
Dec 28, 2007·Cell·Hiroyuki TakaiTitia de Lange
Mar 13, 2008·Genes & Development·Carol M AndersonElizabeth H Blackburn
Apr 17, 2008·The Biochemical Journal·Stefan H MillsonChrisostomos Prodromou
Sep 26, 2009·The EMBO Journal·Harri Lempiäinen, Thanos D Halazonetis
May 11, 2010·Trends in Biochemical Sciences·Christian U StirnimannChristoph W Müller
Aug 31, 2010·Genes & Development·Hiroyuki TakaiNikola P Pavletich
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Sep 29, 2011·Biochimica Et Biophysica Acta·Taras Makhnevych, Walid A Houry
May 3, 2013·Nature·Haijuan YangNikola P Pavletich
May 6, 2014·Structure·Mohinder PalChrisostomos Prodromou
Mar 15, 2015·Frontiers in Genetics·Patrick von MorgenLibor Macurek
Oct 6, 2015·Annual Review of Genetics·Feng He, Allan Jacobson
May 23, 2016·Current Genetics·Rajaneesh Karimpurath Gopinath, Jun-Yi Leu
Dec 10, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Haruna InoueJunko Kanoh
Apr 22, 2017·Nature Reviews. Molecular Cell Biology·Florian H SchopfJohannes Buchner
Jun 18, 2017·Molecular Cell·Andrew N Blackford, Stephen P Jackson
Aug 9, 2017·Trends in Biochemical Sciences·Kliment A Verba, David A Agard

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Citations

Nov 27, 2019·Biochemical Society Transactions·Alberto Elías-VillalobosDominique Helmlinger
Oct 19, 2019·Current Genetics·Minh MaKatsunori Sugimoto
Aug 26, 2020·FEMS Microbiology Reviews·Matan ArbelMartin Kupiec
Jul 25, 2019·Current Genetics·Soumitra Sau, Martin Kupiec
Jan 6, 2019·Cells·Fahd BoutoujaHarald W Platta
Apr 25, 2021·Biochemical and Biophysical Research Communications·Akihiko NakamuraMakio Saeki

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Methods Mentioned

BETA
protein folding
protein-folding

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