Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis

Endocrine Connections
Ursula M M CostaManuel H Aguiar-Oliveira

Abstract

GH and its principal mediator IGF1 have important effects on metabolic and cardiovascular (CV) status. While acquired GH deficiency (GHD) is often associated with increased CV risk, the consequences of congenital GHD are not known. We have described a large group of patients with isolated GHD (IGHD) due to a homozygous mutation (c.57+1G>A) in the GH releasing hormone receptor gene, and shown that adult GH-naïve individuals have no evidence of clinically evident premature atherosclerosis. To test whether subclinical atherosclerosis is anticipated in untreated IGHD, we performed a cross-sectional study of 25 IGHD and 27 adult controls matched for age and gender. A comprehensive clinical and biochemical panel and coronary artery calcium scores were evaluated by multi-detector tomography. Height, weight, IGF1, homeostasis model assessment of insulin resistance, creatinine and creatininekinase were lower in the IGHD group. Median and interquartile range of calcium scores distribution was similar in the two groups: IGHD 0(0) and control 0(4.9). The vast majority of the calcium scores (20 of 25 IGHD (80%) and 18 of 27 controls (66.6%)) were equal to zero (difference not significant). There was no difference in the calcium scores class...Continue Reading

Citations

Dec 24, 2018·Endocrine Reviews·Manuel H Aguiar-Oliveira, Andrzej Bartke
Mar 14, 2019·Endocrine Connections·Ananda A Santana-RibeiroMiburge B Gois-Junior
Mar 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Alécia A Oliveira-SantosManuel H Aguiar-Oliveira
Sep 17, 2020·Reviews in Endocrine & Metabolic Disorders·Manuel H Aguiar-Oliveira, Roberto Salvatori
Jun 13, 2021·Aging Cell·Tatiana D SacconMichal M Masternak

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