BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives

Cancers
Eleonora MolinaroGiulia Rovesti

Abstract

A strong association between pancreatic cancer and BRCA1 and BRCA2 mutations is documented. Based on promising results of breast and ovarian cancers, several clinical trials with poly (ADP-ribose) polymerase inhibitors (PARPi) are ongoing for gastrointestinal (GI) malignancies, especially for pancreatic cancer. Indeed, the POLO trial results provide promising and awaited changes for the pancreatic cancer therapeutic landscape. Contrariwise, for other gastrointestinal tumors, the rationale is currently only alleged. The role of BRCA mutation in gastrointestinal cancers is the subject of this review. In particular, we aim to provide the latest updates about novel therapeutic strategies that, exploiting DNA repair defects, promise to shape the future therapeutic scenario of GI cancers.

References

Nov 2, 1994·Journal of the National Cancer Institute·M L Slattery, R A Kerber
Sep 10, 1998·Nature Genetics·M RedstonK Offit
Aug 5, 1999·Journal of the National Cancer Institute·UNKNOWN Breast Cancer Linkage Consortium
Aug 24, 1999·Diseases of the Colon and Rectum·K M LinH T Lynch
Jul 13, 2002·Journal of Medical Genetics·H TuliniusJ E Eyfjord
Sep 19, 2002·Journal of the National Cancer Institute·Deborah ThompsonUNKNOWN Breast Cancer Linkage Consortium
Sep 19, 2002·Journal of the National Cancer Institute·Marcia S BroseBarbara L Weber
Jan 8, 2004·Journal of the National Cancer Institute·Bethany L NiellStephen B Gruber
Apr 2, 2004·Statistics in Medicine·Jonathan TyrerJack Cuzick
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carmela BegerHans G Beger
Sep 6, 2005·Journal of Medical Genetics·C J van AsperenUNKNOWN Netherlands Collaborative Group on Hereditary Breast Cancer (HEBON)
Jan 15, 2008·Langenbeck's Archives of Surgery·Simona IodiceAlbert B Lowenfels
Jun 30, 2009·American Journal of Epidemiology·Shannon M LynchRachael Z Stolzenberg-Solomon
Apr 13, 2010·Cancer Causes & Control : CCC·Li JiaoRachael Z Stolzenberg-Solomon
Sep 24, 2010·Familial Cancer·Janina SuchySteven A Narod
Apr 14, 2011·Cell Cycle·Konstantin J DedesJorge S Reis-Filho
Sep 14, 2011·Annual Review of Genetics·Lorraine S Symington, Jean Gautier
Dec 14, 2011·Molecular Carcinogenesis·Alison P Klein
Jan 26, 2012·JAMA : the Journal of the American Medical Association·Kelly L BoltonUNKNOWN Cancer Genome Atlas Research Network
Oct 12, 2012·Investigational New Drugs·David DavidsonLawrence Panasci
Oct 27, 2012·British Journal of Cancer·J IqbalUNKNOWN Hereditary Breast Cancer Study Group
Apr 2, 2013·International Journal of Radiation Oncology, Biology, Physics·Joseph W SheltonHui-Kuo G Shu
Dec 3, 2013·British Journal of Cancer·C M PhelanUNKNOWN Hereditary Breast Cancer Study Group
Dec 21, 2013·Molecular Cancer Therapeutics·Junko MuraiYves Pommier
Sep 17, 2014·Cancer·Jacqueline MerschJennifer K Litton
Nov 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bella KaufmanSusan M Domchek
Feb 27, 2015·Nature·Nicola WaddellSean M Grimmond
Jul 17, 2015·JAMA Oncology·Samantha HansfordDavid G Huntsman
Aug 1, 2015·World Journal of Gastroenterology : WJG·Chao LuYou-Ming Li
Aug 11, 2015·Nature Genetics·Hiromi NakamuraTatsuhiro Shibata
Dec 15, 2015·Cancer Discovery·Nicholas J RobertsAlison P Klein
Apr 5, 2016·Clinical Therapeutics·Mary Linton B PetersRebecca A Miksad
Apr 27, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans VasenDetlef K Bartsch
Aug 16, 2016·European Journal of Human Genetics : EJHG·Dominique Stoppa-Lyonnet
Feb 10, 2017·Translational Oncology·Chen WangSusan P Lees-Miller

❮ Previous
Next ❯

Methods Mentioned

BETA
pancreatectomy
prophylactic surgery

Clinical Trials Mentioned

NCT01489865
NCT02890355

Software Mentioned

BRACAnalysis

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.