PMID: 9553742Apr 29, 1998Paper

BRCA1: a review of structure and putative functions

Disease Markers
J W Paterson

Abstract

BRCA1 is a complex gene implicated in familial breast and ovarian cancer. Although it is almost certainly a tumour suppressor, it is also essential for the normal growth and development of embryonic cells. BRCA1 is probably involved in DNA damage and repair, in cell cycle regulation, and in differentiation of cells. It remains to be established whether all these functions are subserved by single mechanism or pathway. Since the cloning of BRCA1 in 1994, much has been learned about the function of the gene. However, a great deal more still has to be uncovered. The size of the protein coded by the BRCA1 gene and the variety of transcripts argues for a complexity of function and regulation that will provide intellectual and technical challenges for years to come.

Citations

Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C X Deng, S G Brodie
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Darci T ButcherDavid I Rodenhiser
Jul 10, 2019·Journal of Translational Medicine·Meysam Moghbeli
May 20, 2000·Annals of the New York Academy of Sciences·D A SpandidosE Aggelakis
Oct 25, 2012·Cancer Metastasis Reviews·Jennifer Dine, Chu-Xia Deng
Jan 13, 2001·Oncogene·J N Hutchinson, W J Muller
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Mar 29, 2002·Environmental and Molecular Mutagenesis·Chu-Xia Deng

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