BRCA1 and BRCA2 mutations in breast and ovarian cancer syndrome: reflection on the Creighton University historical series of high risk families

Familial Cancer
Olga M SinilnikovaGilbert M Lenoir

Abstract

Over the last four decades, Henry Lynch has collected pedigrees and samples from high risk breast and/or ovarian cancer families, generating a unique resource for the study of breast cancer susceptibility. These families have made a major contribution to increasing our knowledge in the cancer genetic susceptibility field, allowing the discovery of a genetic association between breast and ovarian cancer predisposition, contributing to the mapping of the BRCA1 and BRCA2 genes, advancing the idea of the existence of other breast cancer susceptibility genes, allowing the evaluation of BRCA-associated cancer risks and psychosocial aspects of BRCA testing and so on. Ten years after the cloning of BRCA1 and BRCA2, we report the current status of these families and compare the observed BRCA1/2 mutation detection rate with the estimations obtained by linkage analysis of the Breast Cancer Linkage Consortium families.

References

Jul 13, 1991·Lancet·S A NarodG M Lenoir
Dec 1, 1974·Cancer·H T LynchM Brennan
Dec 25, 1972·JAMA : the Journal of the American Medical Association·H T LynchR H Bottomley
Jul 1, 1971·Archives of Surgery·H T Lynch, A J Krush
Nov 1, 1996·Nature Genetics·S MazoyerG M Lenoir
Apr 29, 1998·American Journal of Human Genetics·S MazoyerG M Lenoir
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Deborah ThompsonUNKNOWN KConFab Consortium
Mar 7, 2002·American Journal of Human Genetics·Nadine PugetSylvie Mazoyer
Aug 31, 2004·Carcinogenesis·Olga M SinilnikovaGilbert M Lenoir

❮ Previous
Next ❯

Citations

Apr 21, 2010·Cancer Metastasis Reviews·Andrea TinelliVito Lorusso
Oct 29, 2010·Journal of Occupational Medicine and Toxicology·Céline GasnierGilles-Eric Séralini
Jan 22, 2011·Journal of Occupational Medicine and Toxicology·Céline GasnierGilles-Eric Séralini
Aug 24, 2010·Gastroenterology·Shilpa Grover, Sapna Syngal
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Maurice P ZeegersPiet A van den Brandt
Apr 23, 2009·Molecular Oncology·Susan J Ramus, Simon A Gayther
Feb 22, 2012·Clinical Obstetrics and Gynecology·Jessica Hunn, Gustavo C Rodriguez
Mar 6, 2009·Archives of Pathology & Laboratory Medicine·Chanjuan ShiAlison P Klein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.