BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous Carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Tara ByrneFiona Furlong

Abstract

The aim of this study was to investigate the relationship between BRCA1 and mitotic arrest deficiency protein 2 (MAD2) protein expression, as determined by immunohistochemistry, and clinical outcomes in epithelial ovarian carcinoma (EOC). A tissue microarray consisting of 94 formalin-fixed paraffin-embedded EOC with fully matched clinicopathological data were immunohistochemically stained with anti-BRCA1 and anti-MAD2 antibodies. The cores were scored in a semiquantitative manner evaluating nuclear staining intensity and extent. Coexpression of BRCA1 and MAD2 was evaluated, and patient survival analyses were undertaken. Coexpression of BRCA1 and MAD2 was assessed in 94 EOC samples, and survival analysis was performed on 65 high-grade serous carcinomas (HGSCs). There was a significant positive correlation between BRCA1 and MAD2 expression in this patient cohort (P < 0.0001). Both low BRCA1 and low MAD2 are independently associated with overall survival because of HGSC. Low coexpression of BRCA1 and MAD2 was also significantly associated with overall survival and was driven by BRCA1 expression. BRCA1 and MAD2 expressions are strongly correlated in EOC, but BRCA1 expression remains the stronger prognostic factor in HGSC.

References

Feb 13, 2001·Cell·J V Shah, D W Cleveland
Jun 8, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A GemmaM Emi
Sep 27, 2001·Japanese Journal of Cancer Research : Gann·K TanakaT Nobori
Sep 13, 2003·World Journal of Gastroenterology : WJG·Gang-Qiang LiHong-Fu Zhang
Aug 18, 2004·Cancer Research·Debananda PatiDaniel Medina
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rui-Hong WangChu-Xia Deng
Feb 23, 2005·Current Biology : CB·Kevin G Hardwick
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M ThrallJulie A DeLoia
Jan 30, 2007·Carcinogenesis·Ignacio Pérez de CastroMarcos Malumbres
Dec 21, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer E QuinnD Paul Harkin
May 23, 2009·American Journal of Clinical Pathology·Li WangDaiming Fan
Jan 26, 2012·JAMA : the Journal of the American Medical Association·Kelly L BoltonUNKNOWN Cancer Genome Atlas Research Network
Jun 8, 2012·The Oncologist·Georgios Rigakos, Evangelia Razis
Oct 25, 2012·Journal of Cell Science·Scott C SchuylerVivian Jen-Wei Kuan
Dec 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·James P BeirneW Glenn McCluggage
Aug 2, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Younghye KimYoung-Sik Kim
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 9, 2014·Cell Cycle·J Bargiela-IparraguirreI Sánchez-Pérez
Feb 14, 2015·International Journal of Women's Health·Jermaine Ig CowardFelicity Murphy
Jun 23, 2015·The American Journal of Surgical Pathology·Robertson MackenzieMichael S Anglesio
Mar 16, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Naveena SinghW Glenn McCluggage
May 10, 2017·Histopathology·Naveena SinghC Blake Gilks

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Jan 8, 2021·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sinjini SarkarVilas D Nasare

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