BRCA1, Ki67, and β-Catenin Immunoexpression Is Not Related to Differentiation, Platinum Response, or Prognosis in Women With Low- and High-Grade Serous Ovarian Carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Luis Felipe Trincas Assad SallumSophie Derchain

Abstract

The purpose of this study was to compare the immunohistochemical expression of BRCA1, Ki67, and β-catenin in women with low-grade (LGSOC) and high-grade serous ovarian carcinomas (HGSOC) and their relationship with clinicopathological features, response to platinum-based chemotherapy, and survival. For this study, 21 LGSOC and 85 HGSOC stage I to IV cases, diagnosed and treated from 1996 to 2013 and followed-up until December 2016, were included. BRCA1, Ki67, and β-catenin expression was assessed using tissue microarray-based immunohistochemistry. Women with HGSOC were significantly more likely to have advanced-stage disease (P < 0.001), higher CA125 levels (P < 0.001), postsurgery residual disease (P < 0.01), and higher rates of disease progression and recurrence (P = 0.001). The percentage of women with HGSOC whose tumors expressed Ki67 was significantly higher compared with women with LGSOC (P < 0.001). The expression of BRCA1 and β-catenin did not differ between LGSOC and HGSOC (P = 0.12 and P = 1.00, respectively). The clinicopathological features and the response to platinum-based chemotherapy did not differ according to the BRCA1, Ki67, and β-catenin expression in either group. In HGSOC, only International Federation of ...Continue Reading

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Citations

Nov 28, 2018·Journal of Gynecologic Oncology·Giorgio BoganiFrancesco Raspagliesi
Nov 14, 2019·Journal of Clinical Pathology·Lorena Alves Teixeira, Francisco Jose Candido Dos Reis
Jan 22, 2020·Targeted Oncology·Lorena Alves Teixeira, Francisco Jose Candido Dos Reis
Jan 31, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jacek P GrabowskiJalid Sehouli

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