BRCA1-mediated repression of select X chromosome genes

Journal of Translational Medicine
Amir A JazaeriJ Carl Barrett

Abstract

Recently BRCA1 has been implicated in the regulation of gene expression from the X chromosome. In this study the influence of BRCA1 on expression of X chromosome genes was investigated. Complementary DNA microarrays were used to compare the expression levels of X chromosome genes in 18 BRCA1-associated ovarian cancers to those of the 13 "BRCA1-like" and 14 "BRCA2-like" sporadic tumors (as defined by previously reported expression profiling). Significance was determined using parametric statistics with P < 0.005 as a cutoff. Forty of 178 total X-chromosome transcripts were differentially expressed between the BRCA1-associated tumors and sporadic cancers with a BRCA2-like molecular profile. Thirty of these 40 genes showed higher mean expression in the BRCA1-associated samples including all 11 transcripts that mapped to Xp11. In contrast, four of 178 total X chromosome transcripts showed significant differential expression between BRCA1-associated and sporadic tumors with a BRCA1-like molecular profile. All four mapped to Xp11 and showed higher mean expression in BRCA1-associated tumors. Re-expression of BRCA1 in HCC1937 BRCA1-deficient breast cancer cell resulted in the repression of 21 transcripts. Eleven of the 21 (54.5%) trans...Continue Reading

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Citations

Sep 9, 2008·Breast Cancer Research and Treatment·Yuan SunD Joshua Liao
Apr 21, 2012·Future Oncology·Runhua LiuLizhong Wang
Dec 9, 2004·Pharmacogenomics·Edison T Liu
Oct 30, 2008·Journal of the National Cancer Institute·Felicity LoseUNKNOWN Australian Ovarian Cancer Study Management Group
Apr 26, 2013·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Mohamed HassaneinHagay Sobol
Jul 6, 2007·Nature Reviews. Cancer·Gayle J PageauJeanne B Lawrence
May 2, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joshy GeorgeDavid D Bowtell

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Methods Mentioned

BETA
chip
PCR
transfection

Software Mentioned

BRB Array Tools

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