PMID: 8996544Jan 1, 1997Paper

BRCA1 mutations and phenotype

Journal of Cancer Research and Clinical Oncology
K GradeS Scherneck

Abstract

More than 100 mutations have been described for the breast-cancer-susceptibility gene BRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative gene product, combined with greater severity of the disease.

References

Jul 13, 1991·Lancet·S A NarodG M Lenoir
Mar 1, 1996·Nature Genetics·J T HoltR A Jensen
Jul 1, 1996·Nature Genetics·E V KooninP Bork
Jun 1, 1996·Trends in Biochemical Sciences·A J SaurinP S Freemont
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·K GradeS Scherneck

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Citations

Mar 29, 2002·Environmental and Molecular Mutagenesis·Timothy R Rebbeck
May 15, 1997·The New England Journal of Medicine·B Healy
Apr 8, 1999·Molecular Pathology : MP·J A DuncanT G Cooke
May 2, 2009·Genetic Testing and Molecular Biomarkers·Malinee PongsaveePimpicha Patmasiriwat
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·M M Moore

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