BRCA1 Mutations Associated With Increased Risk of Brain Metastases in Breast Cancer: A 1: 2 Matched-pair Analysis

American Journal of Clinical Oncology
Peter J ZavitsanosKara L Leonard

Abstract

Brain metastases (BM) occur in ∼5% of breast cancer patients. BRCA1-associated cancers are often basal-like and basal-like cancers are known to have a predilection for central nervous system metastases. We performed a matched-pair analysis of breast cancer patients with and without BRCA mutations and compared the frequency of BM in both groups. From a database of 1935 patients treated for localized breast cancer at our institution from 2009 to 2014 we identified 20 patients with BRCA1 or BRCA2 mutations and manually matched 40 patients without BRCA mutations accounting for age, stage, estrogen receptor expression, and human epidermal growth factor receptor 2 (HER2) expression. Comparisons of freedom from brain metastasis, brain metastasis-free survival, and overall survival were made using the log rank test. Testing for a basal-type phenotype using the immunohistochemistry definition (ER/PR/HER2 and either CK 5/6 or EGFR) was performed for BRCA patients who developed BM and their matched controls. We analyzed 60 patients: 20 BRCA and 40 were matched controls. Median follow-up was 37 and 49 months, respectively. Three years freedom from brain metastasis was 84% for BRCA patients and 97% for BRCA controls (P=0.049). Three years b...Continue Reading

References

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Citations

Apr 27, 2019·The Breast Journal·Aditya Shreenivas, Charles L Shapiro
Mar 3, 2020·Journal of the Neurological Sciences·Pitchaya Wanleenuwat, Piotr Iwanowski
Mar 9, 2021·Frontiers in Surgery·Anthony I JangWenya Linda Bi

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Methods Mentioned

BETA
prophylactic oophorectomy

Software Mentioned

Integrated BRAC Analysis

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