BRCA1 mutations in southern England

British Journal of Cancer
D M EcclesI G Campbell

Abstract

If genetic testing for breast and ovarian cancer predisposition is to become available within a public health care system there needs to be a rational and cost-effective approach to mutation analysis. We have screened for BRCA1 mutations in 230 women with breast cancer, all from the Wessex region of southern England, in order to establish the parameters on which to base a cost-effective regional mutation analysis strategy. Truncating mutations were detected in 10/155 (6.5%) consecutive cases selected only for diagnosis under the age of 40 (nine of these ten women had a strong family history of breast or ovarian cancer), 3/61 (4.9%) bilateral-breast cancer cases (all three mutations occurring among women for whom the first cancer was diagnosed under 40 years) and 8/30 (26.6%) breast cancer cases presenting to the genetics clinic (for whom a strong family history of breast and/or ovarian cancer was present). Ten different mutations were detected in 17 families, but three of these accounted for 10/17 (59%) of the families. The cost of screening the population for mutations in the entire BRCA1 gene is unacceptably high. However, the cost of screening a carefully selected patient cohort is low, the risk of misinterpretation much les...Continue Reading

Citations

Jun 26, 2004·Breast Cancer Research : BCR·Karen G MontgomeryIan G Campbell
May 20, 2004·British Journal of Cancer·G L GriffithJ Gray
Sep 15, 2001·British Journal of Cancer·D SteinmannT Dörk
Jun 26, 2004·Breast Cancer Research : BCR·Ian G CampbellUNKNOWN Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer
Dec 11, 2002·Breast Cancer Research : BCR·Ian G CampbellDavid Y H Choong
Jan 16, 2009·Breast Cancer Research : BCR·Diana M Eccles
May 15, 2012·Breast Cancer Research and Treatment·Ella R ThompsonIan G Campbell
May 21, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Fernando AntoñanzasM Pinillos
Apr 17, 2003·British Journal of Cancer·UNKNOWN Scottish/Northern Irish BRCAI/BRCA2 Consortium

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