BRCT domains: A little more than kin, and less than kind.

FEBS Letters
Dietlind L GerloffAlvaro N A Monteiro

Abstract

BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.

References

Oct 7, 1994·Science·P A FutrealY Miki
Jul 1, 1996·Nature Genetics·E V KooninP Bork
Sep 22, 1998·Current Biology : CB·C Featherstone, S P Jackson
Oct 31, 1998·Protein Engineering·I N Shindyalov, P E Bourne
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Aug 10, 2000·Nature·D M Scolnick, T D Halazonetis
Dec 2, 2000·Nature·B B Zhou, S J Elledge
Feb 7, 2001·Human Molecular Genetics·J Vallon-ChristerssonA N Monteiro
Jun 9, 2001·Journal of Molecular Biology·K Pawlowski, A Godzik
Nov 10, 2001·Nature Structural Biology·B L SibandaL Pellegrini
May 8, 2002·Nature Reviews. Molecular Cell Biology·Michael B Yaffe
Jul 12, 2002·The EMBO Journal·Dean J DerbyshireAidan J Doherty
Jul 27, 2002·Science·John Rouse, Stephen P Jackson
Feb 28, 2003·Nature·Grant S StewartStephen J Elledge
Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Stephen C West
Jun 7, 2003·Nature Cell Biology·Arkady CelesteAndré Nussenzweig
Oct 25, 2003·Science·Isaac A MankeMichael B Yaffe
Oct 25, 2003·Science·Xiaochun YuJunjie Chen
Oct 28, 2003·The Journal of Biological Chemistry·Maria RodriguezZhou Songyang
May 11, 2004·Nature Structural & Molecular Biology·Julie A ClappertonStephen J Smerdon
May 11, 2004·Nature Structural & Molecular Biology·R Scott WilliamsJ N Mark Glover
Jun 11, 2004·Annual Review of Biochemistry·Aziz SancarStuart Linn
Jul 10, 2004·Structure·Maria Victoria E BotuyanGeorges Mer
Jul 10, 2004·Cell·Christopher J Bakkenist, Michael B Kastan
Oct 27, 2004·Trends in Biochemical Sciences·J N Mark GloverMegan S Lee
Nov 5, 2004·Nature·Yentram HuyenThanos D Halazonetis
Jan 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lars JelsbakDale Kaiser
Apr 15, 2005·Nature·Vassilis G GorgoulisThanos D Halazonetis
Jun 25, 2005·Protein Engineering, Design & Selection : PEDS·Dinesh C SoaresPaul N Barlow
Aug 17, 2005·Biochemistry·Ashok K VarmaJohn A A Ladias
Jan 18, 2006·EMBO Reports·Jeesun KimMark T Bedford
Feb 17, 2007·Current Opinion in Cell Biology·Jiri Bartek, Jiri Lukas

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Citations

Nov 12, 2014·Nature Communications·Takaaki YasuharaKiyoshi Miyagawa
Jan 10, 2016·Nucleic Acids Research·Guillaume GaullierMarie-Hélène Le Du
Oct 15, 2013·Journal of Molecular and Cellular Cardiology·Ivan A Katrukha, Nikolai B Gusev
Apr 15, 2016·Scientific Reports·Dan HeHuijuan Liu
Oct 18, 2014·Human Genetics·Nicholas T WoodsAlvaro N A Monteiro
Oct 18, 2016·Cell Cycle·Bingbing WanXiaolan Zhao
Apr 9, 2018·Biochemistry. Biokhimii︠a︡·N A Moor, O I Lavrik
Jul 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Wei-Feng YenJayanta Chaudhuri
Nov 28, 2019·International Journal of Molecular Sciences·Kimiko L KriegerNicholas T Woods
May 2, 2020·Signal Transduction and Targeted Therapy·Rui-Xue Huang, Ping-Kun Zhou
Sep 29, 2020·DNA Repair·Ahhyun KimW Matthew Michael

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