Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle

Journal of Virology
Ivar IlvesM Ustav

Abstract

Brd4 protein has been proposed to act as a cellular receptor for the bovine papillomavirus type 1 (BPV1) E2 protein in the E2-mediated chromosome attachment and mitotic segregation of viral genomes. Here, we provide data that show the involvement of Brd4 in multiple early functions of the BPV1 life cycle, suggest a Brd4-dependent mechanism for E2-dependent transcription activation, and indicate the role of Brd4 in papillomavirus and polyomavirus replication as well as cell-specific utilization of Brd4-linked features in BPV1 DNA replication. Our data also show the potential therapeutic value of the disruption of the E2-Brd4 interaction for the development of antiviral drugs.

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Citations

Jun 23, 2012·Nature Reviews. Cancer·Anna C Belkina, Gerald V Denis
Nov 29, 2008·The Journal of Biological Chemistry·A-Young Lee, Cheng-Ming Chiang
Feb 11, 2009·Proceedings. Biological Sciences·Katherine M Feeney, Joanna L Parish
Jul 13, 2007·Journal of Virology·Michal-Ruth SchweigerPeter M Howley
Jun 26, 2009·Journal of Virology·Gang ZhengPeter M Howley
Oct 17, 2008·Journal of Virology·Ammy LinLori Frappier
Oct 23, 2009·Journal of Virology·Vandana SekharAlison A McBride
Feb 9, 2007·Journal of Virology·Mary M DonaldsonIain M Morgan
Jul 15, 2009·Molecular and Cellular Biology·Jianxin YouPeter M Howley
Nov 28, 2013·PLoS Pathogens·Nozomi SakakibaraAlison A McBride
Feb 7, 2012·Biochimica Et Biophysica Acta·Alison A McBrideMoon Kyoo Jang
Dec 31, 2011·Seminars in Cancer Biology·Lori Frappier
Jan 20, 2009·Journal of Medical Virology·Wei-Sheng WangChin Li
Jan 21, 2016·Traffic·Inci Aydin, Mario Schelhaas
Sep 1, 2009·Virology·Suzanne M Melanson, Elliot J Androphy
Jul 16, 2013·Virology·Alison A McBride
Jan 1, 2012·Scientifica·Lori Frappier

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