PMID: 25743841Mar 7, 2015Paper

BRD7 promoter hypermethylation as an indicator of well differentiated oral squamous cell carcinomas

Asian Pacific Journal of Cancer Prevention : APJCP
Anandh BalasubramanianArvind Ramanathan

Abstract

Promoter hypermethylation mediated gene silencing of tumor suppressor genes is considered as most frequent mechanism than genetic aberrations such as mutations in the development of cancers. BRD7 is a single bromodomain containing protein that functions as a subunit of SWI/SNF chromatin-remodeling complex to regulate transcription. It also interacts with the well know tumor suppressor protein p53 to trans- activate genes involved in cell cycle arrest. Loss of expression of BRD7 has been observed in breast cancers and nasopharyngeal carcinomas due to promoter hypermethylation. However, the genetic status of BRD7 in oral squamous cell carcinomas (OSCCs) is not known, although OSCC is one of the most common among all reported cancers in the Indian population. Hence, in the present study we investigated OSCC samples to determine the occurrence of hypermethylation in the promoter region of BRD7 and understand its prevalence. Genomic DNA extracted from biopsy tissues of twenty three oral squamous cell carcinomas were digested with methylation sensitive HpaII type2 restriction enzyme that recognizes and cuts unmethylated CCGG motifs. The digested DNA samples were amplified with primers flanking the CCGG motifs in promoter region of BR...Continue Reading

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Citations

Nov 13, 2019·Biochemical Genetics·Jadwiga GaździckaZofia Ostrowska
Oct 1, 2020·International Journal of Molecular Sciences·Sang Won Park, Junsik M Lee

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