Breadth of Functional Antibodies Is Associated With Plasmodium falciparum Merozoite Phagocytosis and Protection Against Febrile Malaria

The Journal of Infectious Diseases
Ikhlaq Hussain KanaMichael Theisen

Abstract

The specific targets of functional antibodies against Plasmodium falciparum merozoites remain largely unexplored and, more importantly, their relevance to naturally acquired immunity in longitudinal cohort studies (LCSs) is yet to be tested. Functionality of immunoglobulin G (IgG) antibodies against 24 merozoite antigens was determined at the baseline of an LCS in Ghana using a bead-based opsonic phagocytosis assay (BPA). Antigen-specific IgG3 subclass antibodies were quantified in the same samples by the Luminex multiplex system. A wide range of BPA activity was observed across the different antigens. High BPA responses of nMSP3K1, GLURP-R2, MSP23D7, MSP119k, and PfRh2-2030 coupled beads were significantly associated with a higher probability of children not experiencing febrile malaria. Children with high breadth of functional antibodies against these antigens together with cMSP33D7 had a significantly reduced risk of febrile malaria (adjusted hazard ratio, 0.36 [95% confidence interval, .18-.72]; P = .004). Five of the 6 BPA activities significantly (likelihood ratio rest, P ≤ .05) contributed to the protective immunity observed with the IgG3 antibodies. The development of BPA allowed profiling of functional antibodies in an...Continue Reading

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Citations

Feb 1, 2020·Immunology and Cell Biology·Elizabeth H AitkenStephen J Rogerson
Jan 28, 2021·Expert Review of Vaccines·Danielle I Stanisic, Matthew B B McCall
Nov 17, 2020·Frontiers in Immunology·S Jake GonzalesEvelien M Bunnik
Mar 9, 2021·Microbes and Infection·Kai J RogersNoah S Butler
Jun 28, 2021·Vaccine·Sylvester DassahMichael Theisen
Jul 18, 2021·Malaria Journal·Caroline Lin Lin ChuaAndrew Teo

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