Nov 20, 2009

Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables

Journal of Virology
Nicole A Doria-RoseMark Connors

Abstract

Induction of antibodies that neutralize a broad range of human immunodeficiency virus type 1 (HIV-1) isolates is a major goal of vaccine development. To study natural examples of broad neutralization, we analyzed sera from 103 HIV-1-infected subjects. Among progressor patients, 20% of sera neutralized more than 75% of a panel of 20 diverse viral isolates. Little activity was observed in sera from long-term nonprogressors (elite controllers). Breadth of neutralization was correlated with viral load, but not with CD4 count, history of past antiretroviral use, age, gender, race/ethnicity, or route of exposure. Clustering analysis of sera by a novel method identified a statistically robust subgrouping of sera that demonstrated broad and potent neutralization activity.

Mentioned in this Paper

Antibodies, Neutralizing
HIV Infections
Phosphoglycerate Dehydrogenase Activity
CD4 Count Determination Procedure
PHGDH wt Allele
HIV Non-Progressors
Serum
Viral Load Measurement
Neutralization - ActCode
HIV-1

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