Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy

Neurobiology of Disease
Aaron Dadas, Damir Janigro

Abstract

Traumatic brain injury (TBI) accounts for approximately 16% of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for post-traumatic seizures than adults. Post-traumatic seizures are a risk factor for delayed development of epilepsy. Delayed, chronic post-traumatic epilepsy is preceded by a silent period during which therapeutic interventions may arrest, revert or prevent epileptogenesis. A number of recent review articles summarize the most important features of post-traumatic seizures and epilepsy; this review will instead focus on the link between cerebrovascular permeability, epileptogenesis and ictal events after TBI. The possibility of acting on the blood-brain barrier (BBB) and the neurovascular unit to prevent, disrupt or treat post-traumatic epilepsy is also discussed. Finally, we describe the latest quest for biomarkers of epileptogenesis which may allow for a more targeted intervention.

Citations

Oct 9, 2019·Epilepsia·Rachael GarnerDominique Duncan
Jun 20, 2020·Journal of Neuroinflammation·Sanjib MukherjeeLee A Shapiro
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Chengliang HuLigong Chen
Dec 17, 2020·Cells·Masahiro NishiboriHidenori Wake
May 15, 2021·Curēus·Fatima AnwerPousette Hamid
Apr 21, 2020·Current Neuropharmacology·Yam Nath PaudelMohd Farooq Shaikh
Aug 30, 2021·Seizure : the Journal of the British Epilepsy Association·Hanna ErikssonJohan Zelano
Aug 20, 2021·Journal of Occupational and Environmental Medicine·Daniel B LeGoffAimee Peters
Sep 12, 2020·CNS & Neurological Disorders Drug Targets·Shareen SinghAshish Kumar Rehni

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