Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma

Cellular Immunology
H OkaK Nomoto

Abstract

The association between the balance of Th1/Th2 cell responses and CYP11A1 expression in CD4+ T cells was investigated in a murine model implanted with highly metastatic B16F10 melanoma cells (B16F10 mice). When 2 x 10(5) cells/mouse of B16F10 cells were inoculated into C57BL/6 mice, Th2 cell responses and pulmonary metastasis were increased. In addition, corticosterone levels in splenic tissue or serum and CYP11A1 mRNA expression (mRNA encoding cholesterol side-chain cleavage p450 enzyme) in CD4+ T cells were increased in these mice. When the anti-corticosterone drug aminoglutethimide (CYP11A1 inhibitor) was administered to B16F10 mice, corticosterone levels in splenic tissue or serum and CYP11A1 mRNA expression were decreased at 14 days after tumor inoculation. In addition, Th1 cell responses were restored and pulmonary metastasis was reduced by aminoglutethimide. These results indicated that the breakdown of Th cell responses and increase of pulmonary metastasis were due to an increase in steroidogenic CYP11A1 mRNA expression in CD4+ T cells. Moreover, it was suggested that promotion of CYP11A1 mRNA expression in Th2 cells was partially involved due to an increase in level of corticosterone in splenic tissue and the breakdown...Continue Reading

References

Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Oct 1, 1989·Immunological Reviews·T F GajewskiF W Fitch
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederW E Paul
Jul 1, 1993·Immunology Today·G Trinchieri
Jun 1, 1994·The Journal of Experimental Medicine·M S VacchioJ D Ashwell
Apr 1, 1996·Molecular Reproduction and Development·M StrömstedtS K Dey
Jan 1, 1997·Cancer Immunology, Immunotherapy : CII·T TakeuchiK Kawabe
Dec 22, 1998·The Journal of Experimental Medicine·K HungH Levitsky
Sep 8, 1999·The Journal of Experimental Medicine·T NishimuraA Ohta
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D FranchimontJ J O'Shea

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Citations

May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yi JiaErwin W Gelfand
Apr 6, 2004·The Prostate·Alexander FossåErlend B Smeland
Jul 23, 2013·The Journal of Allergy and Clinical Immunology·Meiqin WangErwin W Gelfand
May 4, 2011·Blood·Yoshito TakedaMartin E Hemler
Jan 7, 2017·Oncotarget·Huafeng WangLinjing Zhang
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisabeth H SlagerMarieke Griffioen
Mar 24, 2020·Genes and Immunity·Radomir M SlominskiAndrzej T Slominski
Feb 24, 2006·Radiation Research·Mareyuki Takahashi, Shuji Kojima

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