Breaking down to build up: Neuroligin's C-terminal domain strengthens the synapse

The Journal of Cell Biology
Karen A Newell-Litwa

Abstract

The mechanisms by which neuroligin adhesion molecules modulate synaptic plasticity remain unclear. In this issue, Liu et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509023) demonstrate that neuroligin 1 promotes actin assembly associated with synaptic strengthening independent of adhesion, suggesting additional ways for neuroligins to contribute to neuronal development and disease pathology.

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Citations

Jun 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tao DongYi Zhong

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Methods Mentioned

BETA
GTPase

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