"Breaking news" from spermatids

Basic and Clinical Andrology
Anne GouraudGuylain Boissonneault

Abstract

During the haploid phase of spermatogenesis, spermatids undergo a complex remodeling of the paternal genome involving the finely orchestrated replacement of histones by the highly-basic protamines. The associated striking change in DNA topology is characterized by a transient surge of both single- and double-stranded DNA breaks in the whole population of spermatids which are repaired before spermiation. These transient DNA breaks are now considered part of the normal differentiation program of these cells. Despite an increasing interest in the study of spermiogenesis in the last decade and the potential threat to the haploid genome, the origin of these DNA breaks still remains elusive. This review briefly outlines the current hypotheses regarding possible mechanisms that may lead to such transient DNA fragmentation including torsional stress, enzyme-induced breaks, apoptosis-like processes or oxidative stress. A better understanding of the origin of these DNA breaks will lead to further investigations on the genetic instability and mutagenic potential induced by the chromatin remodeling.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C J Benham
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·E Palecek
Apr 1, 1991·Biology of Reproduction·W S Ward, D S Coffey
Sep 1, 1989·Chromosoma·W S WardD S Coffey
May 1, 1984·Experimental Cell Research·S R Grimes, N Henderson
Mar 1, 1997·Critical Reviews in Toxicology·S VamvakasW K Lutz
Mar 2, 1999·Reviews of Reproduction·D SakkasU Bianchi
Nov 26, 1999·Biology of Reproduction·J Blanco-Rodríguez, C Martínez-García
Jun 8, 2001·Annual Review of Biochemistry·J J Champoux
Aug 3, 2001·The Journal of Biological Chemistry·B BánfiK H Krause
Apr 3, 2004·Genome Research·Kateryna D MakovaFrancesca Chiaromonte
Feb 3, 2005·Nature Reviews. Microbiology·Andrew Travers, Georgi Muskhelishvili
Feb 22, 2005·Journal of Cellular Biochemistry·Piotr Widlak, William T Garrard
Mar 18, 2005·Biology of Reproduction·Rémi-Martin Laberge, Guylain Boissonneault
Apr 20, 2005·Chromosoma·Mirella L Meyer-FiccaRalph G Meyer
Dec 1, 2005·Journal of Cell Science·Sabine M GörischKarsten Rippe
Apr 4, 2006·Human Reproduction Update·Rafael Oliva
Jun 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karin C NitissJohn L Nitiss
Dec 1, 2006·Proceedings. Biological Sciences·Hans Ellegren
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·K Sabeur, B A Ball
Nov 6, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcello CocuzzaAshok Agarwal
Nov 23, 2007·Biology of Reproduction·Frédéric LeducGuylain Boissonneault
Feb 6, 2008·Nature Structural & Molecular Biology·Christophe Lavelle
Dec 2, 2008·Nucleic Acids Research·Joseph E Deweese, Neil Osheroff
Apr 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·Yael Feinstein-Rotkopf, Eli Arama
Aug 4, 2009·Molecular Human Reproduction·R J Aitken, G N De Iuliis
Sep 4, 2009·Cellular and Molecular Life Sciences : CMLS·Junhua ZhaoKaren M Vasquez
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·J-H LeePaul A Marks
Oct 6, 2010·The Journal of Biological Chemistry·Weihong WenZigang Dong
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mandana NamdarPaul A Marks
Dec 15, 2010·Cell Cycle·Brian L HarryDing Xue
Jan 11, 2011·Mutation Research·Thomas B KrystonAlexandros G Georgakilas
Feb 15, 2011·Molecular Human Reproduction·M C O CavalcantiK Steger
Apr 7, 2011·Transcription·Joaquim Roca
Jan 1, 2008·Genome Dynamics and Stability·Scott Keeney
Sep 29, 2011·PloS One·Hanna M KorhonenNoora Kotaja

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Citations

Nov 4, 2017·Biology of Reproduction·Ralph G MeyerMirella L Meyer-Ficca
Aug 20, 2014·Human Mutation·Olivier SimardGuylain Boissonneault
Dec 24, 2018·International Journal of Molecular Sciences·Anaís García-RodríguezStephen Johnston
Jul 6, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·E A ArifulinE V Sheval

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