Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts

Angewandte Chemie
Angeles CanalesJesús Jiménez-Barbero

Abstract

Controlling NMR shifts by lanthanides tagged to a "symmetrical" N-glycan reveals individual resonances for the residues of the otherwise identical A and B arms. This method provides a global perspective of conformational features and interactions in solution.

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Citations

Sep 30, 2015·Current Opinion in Structural Biology·Masamichi Nagae, Yoshiki Yamaguchi
May 2, 2015·Glycoconjugate Journal·Maho Yagi-Utsumi, Koichi Kato
Apr 12, 2017·Journal of Chemical Theory and Computation·Raimondas GalvelisYuji Sugita
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