Breaking the barrier in stroke: what should we know? A mini-review.

Current Pharmaceutical Design
Cesar V BorlonganMaria Carolina Oliveira

Abstract

The blood-brain barrier (BBB) has been considered as an important regulator of brain homeostasis, and its disturbance has been implicated in the onset and/or evolution of many pathological manifestations of neurodegenerative and inflammatory diseases [1, 2]. In particular, BBB breakdown has been closely associated with the primary insult, as well as the secondary cell death of stroke. Here, we review the pioneering contributions of leading scientists who have vested interest in advancing our understanding of the pivotal role of BBB in stroke, but also exploiting this knowledge in developing novel BBB-based therapeutic regimens to abrogate stroke symptoms. The study of BBB as a fundamental research theme and as a target for clinical applications in stroke can be approached in three main themes namely, basic science research, translational and clinical research, and emerging therapies for BBB repair in stroke. This minireview captures cutting-edge discoveries establishing BBB as a central target for abetting neuroprotection and neurorestoration in stroke.

Citations

Feb 3, 2015·Experimental & Translational Stroke Medicine·Sung-Ha HongLudmila Belayev
Nov 10, 2015·Biochemical Society Transactions·Keith D Rochfort, Philip M Cummins
Apr 24, 2019·Journal of Clinical Medicine·Sydney ZarrielloCesario V Borlongan
Apr 13, 2017·Journal of Nanobiotechnology·Andrés Da Silva-CandalJosé Castillo
Oct 27, 2016·Immunological Reviews·Ali Alawieh, Stephen Tomlinson
Jan 18, 2020·Scientific Reports·Verónica Viñuela-BerniAndrés Quintanar-Stephano
Jan 28, 2021·International Journal of Molecular Sciences·Ayon BhattacharyaSylvain Doré
May 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jiyao ZhangLuwen Zhu
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Chenglong GaoTao Pang

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