May 14, 2020

Breaking the Impasse: Advances in Treatment of Small Cell Lung Cancer

Clinics in Chest Medicine
Andreas Saltos, Scott Antonia

Abstract

Small cell lung cancer (SCLC) is an aggressive malignancy and carries a poor prognosis with limited effective treatments in the advanced setting. SCLC is characterized by a high tumor mutation burden and alterations in Notch signaling and DNA damage repair pathways, providing rationale for the use of immunotherapy and targeted therapies. Immunotherapies have led to the most significant advances in treating SCLC in decades, and several promising targeted approaches have emerged from the increased understanding of the biology of SCLC. However, responses to these novel approaches are far from universal, and efforts to refine these therapies are ongoing.

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Mentioned in this Paper

Immunotherapy
DNA Repair
Malignant Neoplasms
NOTCH1
Prognosis Bad
Notch Signaling Pathway
Gene Mutation
Small Cell Carcinoma of Lung

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