Breaking through to the Other Side: Microenvironment Contributions to DCIS Initiation and Progression

Journal of Mammary Gland Biology and Neoplasia
Andrew C NelsonKathryn L Schwertfeger

Abstract

Refinements in early detection, surgical and radiation therapy, and hormone receptor-targeted treatments have improved the survival rates for breast cancer patients. However, the ability to reliably identify which non-invasive lesions and localized tumors have the ability to progress and/or metastasize remains a major unmet need in the field. The current diagnostic and therapeutic strategies focus on intrinsic alterations within carcinoma cells that are closely associated with proliferation. However, substantial accumulating evidence has indicated that permissive changes in the stromal tissues surrounding the carcinoma play an integral role in breast cancer tumor initiation and progression. Numerous studies have suggested that the stromal environment surrounding ductal carcinoma in situ (DCIS) lesions actively contributes to enhancing tumor cell invasion and immune escape. This review will describe the current state of knowledge regarding the mechanisms through which the microenvironment interacts with DCIS lesions focusing on recent studies that describe the contributions of myoepithelial cells, fibroblasts and immune cells to invasion and subsequent progression. These mechanisms will be considered in the context of developing...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
May 6, 1995·Lancet·M J SilversteinD J Slamon
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D LazardV E Koteliansky
Dec 31, 1997·The Journal of Cell Biology·G L RadiceR O Hynes
Feb 2, 2000·Nature Medicine·M ZhangN Bouck
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Jul 9, 2002·Breast Cancer Research : BCR·Charles H Streuli
Dec 11, 2002·Breast Cancer Research : BCR·Marie-Ange DeugnierMarina A Glukhova
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KuperwasserRobert A Weinberg
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Sep 20, 2005·Breast Cancer Research : BCR·Melissa C AdrianceMina J Bissell
Mar 11, 2006·Cancer Genetics and Cytogenetics·Cristina CorzoFrancesc Solé
Jun 3, 2006·Cancer Research·Kathryn L SchwertfegerJeffrey M Rosen
Jun 30, 2006·Journal of Mammary Gland Biology and Neoplasia·Sanford H Barsky, Nina J Karlin
Jun 30, 2006·Journal of Mammary Gland Biology and Neoplasia·Thorarinn GudjonssonMina J Bissell
Oct 10, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wendy V IngmanJeffrey W Pollard
Dec 28, 2006·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Boye S NielsenKeld Danø
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Andrea Page-McCawZena Werb
Jan 7, 2009·Archives of Pathology & Laboratory Medicine·Susan C LesterUNKNOWN Members of the Cancer Committee, College of American Pathologists
Feb 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Min HuKornelia Polyak
Oct 8, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mary L Disis, Kyong Hwa Park
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Puspa Raj PandeyKounosuke Watabe
Jul 2, 2010·Cold Spring Harbor Perspectives in Biology·Kornelia Polyak, Raghu Kalluri
Dec 8, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kyung Eun SungDavid J Beebe
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brian RuffellLisa M Coussens
Sep 13, 2011·Cancer Cell·Zvi GranotRobert Benezra
May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Patrick R Lawler, Jack Lawler
Aug 16, 2012·Molecular Cancer Research : MCR·Laura R Bohrer, Kathryn L Schwertfeger
May 4, 2013·Journal of the National Cancer Institute·Lawrence J SolinSunil Badve
Jul 31, 2013·Molecular Oncology·Catherine F CowellJorge S Reis-Filho
Sep 21, 2013·Nature Immunology·Thomas F GajewskiYang-Xin Fu
Oct 24, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael D AllenJ Louise Jones
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Nov 7, 2019·The FEBS Journal·Jessica R HitchcockChristine J Watson
Mar 3, 2020·Integrative Biology : Quantitative Biosciences From Nano to Macro·Molly M MorganDavid J Beebe
Sep 11, 2019·Cold Spring Harbor Perspectives in Medicine·Asmaa El-KenawiBrian Ruffell
Apr 26, 2020·Molecular Carcinogenesis·Umayal SivagnanalingamOlivera J Finn
Jan 8, 2020·Journal of Cellular Biochemistry·Rebecca S DeVauxJason I Herschkowitz
Sep 21, 2019·Journal of Breast Imaging·Mariam ShehataHabib Rahbar
Apr 3, 2020·PLoS Biology·Carlos Sonnenschein, Ana M Soto
Oct 28, 2019·Frontiers in Immunology·Madhav V Dhodapkar, Kavita M Dhodapkar
Jan 27, 2019·Journal of Mammary Gland Biology and Neoplasia·Eirikur BriemThorarinn Gudjonsson
Apr 3, 2020·Cancer Immunology Research·Carlos R Gil Del AlcazarKornelia Polyak
Oct 22, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brian L SpragueMatthew W Conklin
Jan 15, 2021·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jonathan KulwatnoKristen L Mills
Apr 17, 2019·Trends in Cell Biology·Kunihiko Hinohara, Kornelia Polyak
Jul 3, 2021·Cancers·Patricia Fernández-NogueiraPaloma Bragado
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Carmen Moccia, Kristina Haase

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.