Breaking up of prolonged sitting over three days sustains, but does not enhance, lowering of postprandial plasma glucose and insulin in overweight and obese adults

Clinical Science
R N LarsenDavid W Dunstan

Abstract

To compare the cumulative (3-day) effect of prolonged sitting on metabolic responses during a mixed meal tolerance test (MTT), with sitting that is regularly interrupted with brief bouts of light-intensity walking. Overweight/obese adults (n=19) were recruited for a randomized, 3-day, outpatient, cross-over trial involving: (1) 7-h days of uninterrupted sitting (SIT); and (2) 7-h days of sitting with light-intensity activity breaks [BREAKS; 2-min of treadmill walking (3.2 km/h) every 20 min (total: 17 breaks/day)]. On days 1 and 3, participants underwent a MTT (75 g of carbohydrate, 50 g of fat) and the incremental area under the curve (iAUC) was calculated from hourly blood samples. Generalized estimating equation (GEE) models were adjusted for gender, body mass index (BMI), energy intake, treatment order and pre-prandial values to determine effects of time, condition and time × condition. The glucose iAUC was 1.3 ± 0.5 and 1.5 ± 0.5 mmol·h·l(-1) (mean differences ± S.E.M.) higher in SIT compared with BREAKS on days 1 and 3 respectively (condition effect: P=0.001), with no effect of time (P=0.48) or time × condition (P=0.8). The insulin iAUC was also higher on both days in SIT (day 1: ∆151 ± 73, day 3: ∆91 ± 73 pmol·h·l(-1), P...Continue Reading

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Citations

Oct 5, 2016·Current Diabetes Reports·Paddy C DempseyDavid W Dunstan
Jan 25, 2017·Exercise and Sport Sciences Reviews·Sophie CarterNicola D Hopkins
Jul 9, 2016·Medicine and Science in Sports and Exercise·Nabeha S A HawariJason M R Gill
Mar 25, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Robyn N LarsenDavid W Dunstan
May 26, 2017·The Journal of Physiology·Corey A RyndersAudrey Bergouignan
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Jul 27, 2021·Medicine and Science in Sports and Exercise·Jennifer M BlankenshipDavid W Dunstan

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