Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion

Pharmacology & Therapeutics
Karina ReissPaul Saftig

Abstract

Cell adhesion and cell migration are essential for a variety of important events in both embryonic development and in the adult organism. Cell adhesion molecules (CAM) like selectins, immunoglobulin superfamily members, integrins, and cadherins undergo diverse mechanisms of regulation. Dysregulation of adhesion can lead to pathological processes, including inflammatory diseases or tumor metastasis either by disrupting the normal anchorage, thereby altering cell movement and regulatory signalling, or by promoting inappropriate temporal and spatial adhesion. An increasing body of evidence has emerged showing that members of the a disintegrin and metalloproteinase (ADAM) family critically contribute to the regulation of CAM functions. While the disintegrin domain can interact with integrins and mediate adhesion, the metalloproteinase domain can mediate anti-adhesive functions by cleaving the membrane bound adhesion molecules. This "shedding" process leads to the release of often still functional soluble ectodomains and can additionally influence intracellular cell signalling pathways. Several soluble CAMs have been detected in vitro and in vivo. Some of them are strongly increased in inflammatory diseases or in the serum of cancer...Continue Reading

References

Dec 4, 1992·Annals of the New York Academy of Sciences·A J GearingS J Cashman
Jan 1, 1992·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·M FerdeghiniP Fioretti
Apr 1, 1992·The Journal of Experimental Medicine·L C DunlopM C Berndt
Oct 1, 1992·The Journal of Cell Biology·B SchleiffenbaumT F Tedder
Sep 16, 1992·Biochemical and Biophysical Research Communications·R PigottA J Gearing
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Pandiella, J Massagué
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Nov 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·R J GouldS Niewiarowski
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Nov 1, 1994·European Journal of Immunology·M A del PozoF Sánchez-Madrid
Apr 1, 1995·The Journal of Clinical Investigation·F Díaz-GonzálezF Sánchez-Madrid
Feb 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·W Birchmeier
Mar 1, 1994·British Journal of Cancer·M KatayamaI Kato
Sep 1, 1993·Clinical & Experimental Metastasis·A KowitzP Altevogt
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A BensussanL Boumsell
Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
May 17, 1996·The Journal of Biological Chemistry·G PreeceA Ager
Feb 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F RevillionJ P Peyrat
Oct 1, 1996·Current Opinion in Cell Biology·J A Varner, D A Cheresh
Jan 1, 1997·Developmental Biology·G L RadiceR O Hynes
Jan 15, 1997·The Biochemical Journal·N M HooperA J Turner
Feb 13, 1997·Nature·J F BazanT J Schall
Jan 1, 1997·Investigational New Drugs·S M Wojtowicz-PragaM J Hawkins
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A DietrichJ C Simon
Dec 31, 1997·The Journal of Cell Biology·G L RadiceR O Hynes

❮ Previous
Next ❯

Citations

Dec 7, 2007·Pflügers Archiv : European journal of physiology·Thomas LudwigUlrich S Schwarz
Apr 17, 2008·Molecular Neurobiology·Hyang-Sook Hoe, G William Rebeck
Dec 18, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Ana StojanovicAdelheid Cerwenka
Jan 16, 2013·The Journal of Laryngology and Otology·S ErbekL N Ozluoglu
Nov 14, 2008·Nature Reviews. Cancer·Gillian Murphy
Oct 15, 2010·The Journal of Biological Chemistry·Antonio Velayos-BaezaAnthony P Monaco
Jul 16, 2010·BMC Evolutionary Biology·Shuo WeiDouglas W Desimone
Jul 24, 2010·BMC Genomics·Elen AnatrielloBeatriz R Ferreira
Dec 31, 2008·Cell Communication and Signaling : CCS·Matthias VossOttmar Janssen
Sep 13, 2011·Clinical Proteomics·Michael J DuffyPatricia M McGowan
Mar 6, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Luz Marina AcevedoMoise Bendayan
May 22, 2013·PloS One·Megan Y MurrayJelena Gavrilovic
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea MegillHyang-Sook Hoe
Nov 6, 2012·Fertility and Sterility·Hsiu-Ting TsaiPo-Hui Wang
Jan 5, 2011·Trends in Molecular Medicine·Helena KiefelPeter Altevogt
Jan 5, 2011·European Journal of Cell Biology·Paul Saftig, Karina Reiss
Jan 29, 2011·Reproductive Biomedicine Online·I Van VaerenberghC Bourgain
Sep 1, 2015·Experimental Eye Research·Debasish SinhaJames T Handa
Dec 1, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yanping ZhaLianqun Cui
May 2, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael J DuffyPatricia M McGowan
Oct 31, 2008·The Journal of Investigative Dermatology·Ulf AndereggJan C Simon
Dec 4, 2008·Seminars in Cell & Developmental Biology·Karina Reiss, Paul Saftig
Oct 22, 2008·Seminars in Cell & Developmental Biology·Dominique AlfandariHélène Cousin
Oct 9, 2008·Seminars in Cell & Developmental Biology·Gillian Murphy
Oct 28, 2008·Seminars in Cell & Developmental Biology·Jessica Pruessmeyer, Andreas Ludwig
Mar 18, 2008·The International Journal of Biochemistry & Cell Biology·Marie KveiborgUlla M Wewer
Jan 10, 2008·Trends in Immunology·Gillian MurphyRama Khokha
May 1, 2007·Biochemical and Biophysical Research Communications·A SchulteA Ludwig
Mar 28, 2008·The British Journal of Dermatology·S T OhJ Reichrath
Jan 30, 2010·International Journal of Cancer. Journal International Du Cancer·Hiroaki KurodaYasunori Okada
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jakob V WeissIrmgard Schwarte-Waldhoff
Jul 30, 2010·International Journal of Experimental Pathology·Gillian Murphy
Apr 29, 2014·Journal of Cellular Biochemistry·Polly J Phillips-MasonSusann M Brady-Kalnay
Mar 31, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·T KauttuP Puolakkainen
Nov 19, 2013·Biochemical and Biophysical Research Communications·Silvio WeberPaul Saftig
Jun 7, 2011·Biochimica Et Biophysica Acta·Vitaliy Kaminskyy, Boris Zhivotovsky
Jul 17, 2012·Cell Adhesion & Migration·Helena KiefelPeter Altevogt
Sep 16, 2008·Osteoarthritis and Cartilage·J Rodriguez-LopezA Gonzalez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Nature Reviews. Molecular Cell Biology
Carl P Blobel
Proceedings of the National Academy of Sciences of the United States of America
Thorsten MaretzkyPaul Saftig
Trends in Biochemical Sciences
Ari-Pekka J HuovilaRebekka M Ortiz
© 2022 Meta ULC. All rights reserved