Breakpoints for posaconazole susceptibility testing: background and discussion about the need of establishing values

Mycoses
R Fleck, H Hof

Abstract

Posaconazole is a new antifungal agent, which exhibits a broad spectrum of activity against fungi including Aspergillus terreus, some zygomycetes and dematiaceous fungi. Out of the group of triazole antifungal agents, it is the only compound for which interpretive breakpoints have not been established have not yet been established for Candida spp. As reliable breakpoints are useful in the practical management of patients with fungal infections, it is desirable to establish the same for all available substances. However, the underlying data of the existing breakpoints for other antifungal agents are of varying quality because of limited clinical data available. Furthermore, these breakpoints are not equally suitable for all testing methods available and they may not be suitable for all species to be tested. From the practical point of view, it is therefore important not only to establish breakpoints for the reference method but also for the inexpensive and easy to perform testing methods, which are suitable for smaller laboratories.

References

Jun 1, 1997·Antimicrobial Agents and Chemotherapy·D W DenningS L Kelly
Nov 18, 1998·The Journal of Antimicrobial Chemotherapy·C Lass-FlörlD Niederwieser
Aug 23, 2001·International Journal of Antimicrobial Agents·K UchidaH Yamaguchi
Oct 2, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John H Rex, Michael A Pfaller
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jo-Anne H van BurikDimitrios P Kontoyiannis
Jan 26, 2007·The New England Journal of Medicine·Oliver A CornelyDavid Angulo-Gonzalez
May 23, 2007·Expert Opinion on Pharmacotherapy·Douglas S Kwon, Eleftherios Mylonakis

❮ Previous
Next ❯

Citations

Oct 22, 2009·Natural Product Research·Berenice Aguilar-GuadarramaMaría Yolanda Rios
Jan 11, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Nlandu R NgatuNarufumi Suganuma
Nov 26, 2009·Drugs·Antonino Gullo
Feb 1, 2010·Journal of Pharmacy Practice·Elizabeth A Coyle
Oct 15, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Claus SeebacherHans-Jürgen Tietz
Jul 1, 2016·Current Fungal Infection Reports·Bart G J DekkersJan-Willem C Alffenaar
May 17, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maximiliano SortinoSusana Zacchino
Jun 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrícia L A NascimentoTania M S Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.