Breakthrough in P450 bioelectrochemistry and future perspectives

Biochimica Et Biophysica Acta
Sheila J SadeghiGianfranco Gilardi

Abstract

Improving the electrochemical performance of cytochrome P450 enzymes is highly desirable due to their versatility in the recognition of different biological and xenobiotic compounds. The task poses an exciting challenge because it leads not only to the acquisition of fundamental knowledge on the redox properties of these enzymes, but it also opens opportunities for technological and commercial applications. Interfacing these enzymes to electrode surfaces and electrochemically driving their catalytic cycle has proven to be very difficult. Initial attempts made by several groups included the direct immobilisation of these enzymes on electrode surfaces and omission of their redox partners for simplification of their electron transfer pathway. The data obtained in these cases generally resulted in a high heterogeneous electron transfer rate but without success in terms of detectable substrate turnover. The breakthrough in electrocatalysis has been made when both the electrode and the enzyme have been engineered, in some cases mimicking the natural environment of the microsomal enzymes and the inclusion of their electron transfer partners. This paper reviews and discusses the recent literature on this subject, and highlights the dif...Continue Reading

References

Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·V ReipaV L Vilker
Feb 19, 2000·Biochemical and Biophysical Research Communications·C LeiF W Scheller
Feb 24, 2001·Faraday Discussions·S J SadeghiG Gilardi
Aug 10, 2001·Current Opinion in Structural Biology·G GilardiS J Sadeghi
Apr 19, 2005·Journal of Inorganic Biochemistry·Victoria V ShumyantsevaAlexander I Archakov
Apr 28, 2005·Biosensors & Bioelectronics·Nikitas BistolasFrieder W Scheller
Sep 6, 2005·Biochemical and Biophysical Research Communications·Andrew K Udit, Harry B Gray
Sep 30, 2005·Journal of the American Chemical Society·Nasreen SultanaJames F Rusling
Nov 12, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Michael FairheadGianfranco Gilardi
Mar 16, 2006·Chemical Communications : Chem Comm·Andrea FantuzziGianfranco Gilardi
Apr 6, 2006·Journal of Molecular Endocrinology·D L JohnsonL L Martin
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·Barry D FlemingLisandra L Martin
Jul 25, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Vikash Rajnikant DodhiaGianfranco Gilardi
Nov 30, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew K UditHarry B Gray
Oct 24, 2007·Journal of the American Chemical Society·Aditi DasStephen G Sligar
Nov 27, 2007·Electrochemistry Communications·Sadagopan Krishnan, James F Rusling
Jan 28, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mingli YangNianqiang Wu
May 1, 2009·Journal of the American Chemical Society·Yasuhiro MieYasuo Komatsu

❮ Previous
Next ❯

Citations

Oct 23, 2013·Biosensors & Bioelectronics·C Baj-RossiS Carrara
Sep 18, 2013·Journal of the American Chemical Society·Ngoc-Han TranLionel E Cheruzel
Oct 7, 2011·Chemical Communications : Chem Comm·Ngoc-Han TranLionel E Cheruzel
Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Steven L Kelly, Diane E Kelly
May 23, 2014·Applied Microbiology and Biotechnology·Rita Bernhardt, Vlada B Urlacher
Jan 30, 2013·Trends in Biochemical Sciences·Andrew W MunroKirsty J McLean
Jul 20, 2012·Biosensors & Bioelectronics·Elizabeth Schneider, Douglas S Clark
Mar 12, 2016·Bioconjugate Chemistry·Sarah ZerniaAnnette G Beck-Sickinger
Apr 30, 2013·Electroanalysis·Dhanuka P WasalathanthriJames F Rusling
Sep 10, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O V GnedenkoA I Archakov
Apr 9, 2014·Current Opinion in Plant Biology·Hugues RenaultDanièle Werck-Reichhart
Oct 19, 2016·Molecular and Cellular Endocrinology·Lisandra L MartinRaymond J Rodgers
Jun 20, 2017·Biochimica Et Biophysica Acta. Proteins and Proteomics·Julie Ducharme, Karine Auclair
Apr 17, 2013·Biotechnology and Applied Biochemistry·Sheila J Sadeghi, Gianfranco Gilardi
May 4, 2018·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A V KuzikovV V Shumyantseva
Feb 28, 2013·International Journal of Molecular Sciences·Giovanna Di Nardo, Gianfranco Gilardi
Dec 8, 2019·The Journal of Biological Chemistry·Zhong LiWei Zhang
Jul 28, 2020·Biotechnology and Applied Biochemistry·Sheila J SadeghiGianfranco Gilardi
Jul 20, 2016·Microbial Cell Factories·Pradeepraj DurairajHyungdon Yun
Sep 27, 2018·International Journal of Molecular Sciences·Gerardo ZambranoAngela Lombardi
Apr 23, 2014·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O V GnedenkoA I Archakov
May 16, 2020·Trends in Biochemical Sciences·Giovanna Di Nardo, Gianfranco Gilardi
Jun 11, 2017·Biochimica Et Biophysica Acta. Proteins and Proteomics·Hadil ShalanLionel Cheruzel
Sep 27, 2020·Journal of Inorganic Biochemistry·Celine Eidenschenk, Lionel Cheruzel
May 8, 2021·Analytical Biochemistry·Moumita RayShyamalava Mazumdar
May 4, 2021·Frontiers in Microbiology·James B Y H Behrendorff
Sep 16, 2018·Biosensors & Bioelectronics·Victoria V ShumyantsevaAlexander I Archakov
Nov 26, 2010·Analytical Chemistry·Andrea FantuzziGianfranco Gilardi
Apr 8, 2011·Analytical Chemistry·Andrea FantuzziGianfranco Gilardi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.