Breakthrough of 225Ac and its radionuclide daughters from an 225Ac/213Bi generator: development of new methods, quantitative characterization, and implications for clinical use

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
D MaDavid A Scheinberg

Abstract

Bisumth-213, a short-lived alpha particle emitting radionuclide, is generated from the decay of 225Ac, which has a half-life of 10 days. The development of a clinical 225Ac/213Bi generator and the preparation of a 213Bi radiolabeled antibody for radioimmunotherapy of leukemia have been reported. The 225Ac decay scheme is complex; therefore a thorough understanding of the impact of both the parent 225Ac and its daughters on radiolabeling, purification, and quantification is necessary for optimal use of the generator system. This paper reports: (i) unique new methods to measure 221Fr, 213Bi, and 209Pb, the prominent daughters of 225Ac; and (ii) a quantitative evaluation of 225Ac/213Bi generator breakthrough and the radionuclidic purity of 213Bi labeled radiopharmaceutical dose formulations. A quantitative multi-dimensional proportional scanning method was employed to distinguish and measure specific daughter radionuclides. This method combines thin layer chromatography in two perpendicular directions with attenuated collimation as a function of time for data collection and analysis. Francium-221 and 213Bi eluted differentially from the generator, and 221Fr contributed minimally to unchelated 213Bi in the reaction and final produc...Continue Reading

References

Apr 24, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Michael R McDevittDavid A Scheinberg
Sep 3, 1999·Nuclear Medicine and Biology·I A DavisS J Kennel
Aug 15, 2000·Cancer Biotherapy & Radiopharmaceuticals·S J KennelSaed Mirzadeh

Citations

Apr 21, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Olivier CouturierMichel Cherel
Dec 7, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Young-Seung Kim, Martin W Brechbiel
Apr 4, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Dalia NayakA Ramaswami
Mar 8, 2014·Pharmaceuticals·Wiebke SihverHans-Jürgen Pietzsch
Sep 4, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S PomméAlfred Morgenstern
Mar 15, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Rose A BollSaed Mirzadeh
Feb 17, 2015·Nuclear Medicine and Biology·Justin J WilsonEva R Birnbaum
May 30, 2014·Targeted Oncology·Evan D ReadTerrence J Piva
Feb 25, 2015·Cancer Biotherapy & Radiopharmaceuticals·Ashutosh DashFurn F Russ Knapp
Jan 10, 2008·Bulletin of Environmental Contamination and Toxicology·C E KollerG R MacFarlane
Jun 26, 2004·Blood·Rui Rong YuanDavid A Scheinberg
Sep 13, 2017·Expert Opinion on Drug Delivery·Carlos Daniel MartinsWim J G Oyen
Apr 20, 2013·Chemical Communications : Chem Comm·Caterina F Ramogida, Chris Orvig
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey P NorenbergLarry K Kvols

Related Concepts

Actinium
Bismuth
Francium
Lead Radioisotopes
Leukemia
Radiochemistry
Radioisotopes
Radioimmunotherapy
Radiopharmaceuticals

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
D MaDavid A Scheinberg
Current Radiopharmaceuticals
Alfred MorgensternC Apostolidis
Cancer Biotherapy & Radiopharmaceuticals
S J KennelSaed Mirzadeh
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Michael R McDevittDavid A Scheinberg
© 2021 Meta ULC. All rights reserved