Abstract
The aim of this study was to determine the severity of breakthrough reactions to gadobenate dimeglumine in patients premedicated with a 13-hour premedication regimen. Institutional review board approval was obtained and informed consent waived for this Health Insurance Portability and Accountability Act-compliant retrospective cohort study. All acute allergic-like reactions to gadobenate dimeglumine from 11/1/2008 to 1/31/2016 were identified. Of these, 19 allergic-like reactions followed 13-hour premedication: 150 mg prednisone and 50 mg diphenhydramine (ie, "breakthrough reactions"). Reasons for premedication, risk factors, index reaction characteristics, and breakthrough reaction characteristics were catalogued. Reaction severities were assigned using American College of Radiology guidelines. Severities of breakthrough (n = 19) and nonbreakthrough reactions (n = 97) were compared with the Cochran-Armitage test for trend. Premedication was most commonly given (63% [12/19]) for a previous allergic-like reaction to gadolinium-based contrast material (GBCM); in 37% (7/19), it was given for a different risk factor. In those premedicated for a previous allergic-like reaction to GBCM of known severity (n = 9), the breakthrough reac...Continue Reading
References
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·P A Greenberger, R Patterson
Oct 1, 1987·The New England Journal of Medicine·E C LasserH O Stolberg
Oct 1, 1984·The Journal of Allergy and Clinical Immunology·P A GreenbergerR C Radin
Aug 1, 1995·Radiology·K L NelsonT A Lasser
Mar 1, 1994·AJR. American Journal of Roentgenology·E C LasserJ M Silverman
Dec 21, 2007·AJR. American Journal of Roentgenology·Jonathan R DillmanSophia C Jan
Jul 24, 2008·AJR. American Journal of Roentgenology·Carolyn L WangIsaac R Francis
Oct 1, 2009·Radiology·Matthew S DavenportJames H Ellis
Jan 21, 2011·Radiology·Desiree E MorganDavid N Bolus
Jan 25, 2011·AJR. American Journal of Roentgenology·Martin R PrincePaula W Brill
May 3, 2011·Journal of the American College of Radiology : JACR·Ryan B O'MalleyJames D Myles
May 3, 2012·Radiology·Jae-Woo JungSang-Heon Cho
Dec 15, 2012·Radiology·Matthew S DavenportJames H Ellis
Apr 26, 2016·Radiology·Sarah PowerDaniel M Mandell
Aug 29, 2017·Radiology·Ashkan Heshmatzadeh BehzadiMartin R Prince
Jan 23, 2018·Radiology·Matthew S Davenport
Citations
Apr 12, 2019·AJR. American Journal of Roentgenology·Nicola SchiedaMatthew S Davenport
Apr 30, 2019·Investigative Radiology·Chang Hyun RyooWhal Lee
Mar 19, 2019·Investigative Radiology·Daniel WalkerNicola Schieda
May 20, 2020·Radiology·Daniel T WalkerNicola Schieda
Dec 19, 2020·Investigative Radiology·Daniel WalkerNicola Schieda