Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys

The Journal of Clinical Endocrinology and Metabolism
Charles E WoodJ Mark Cline

Abstract

In this study we evaluated the long-term effects of soy isoflavones on intermediate markers of cancer risk in the normal postmenopausal monkey breast and uterus. Ovariectomized female cynomolgus monkeys were randomized to receive one of three diets for 36 months: 1) isoflavone-depleted soy protein isolate (SPI-) (n = 57); 2) soy protein isolate with the equivalent of 129 mg/d isoflavones (SPI+) (n = 60); or 3) isoflavone-depleted soy protein isolate with conjugated equine estrogens at a dose scaled to approximate 0.625 mg/d in women (n = 62). End points included breast and uterine proliferation markers, sex steroid receptor expression, and serum estrogens. Epithelial proliferation and progesterone receptor expression in the breast and uterus were significantly higher in the conjugated equine estrogen group, compared with SPI+ and SPI- groups, whereas no significant differences were detected between the SPI+ and SPI- groups. SPI+ treatment resulted in significantly lower serum concentrations of estrone (P < 0.01) and estradiol (P < 0.05) vs. SPI-. Within the SPI+ group, serum isoflavone concentrations were inversely correlated with serum estrone and mammary glandular area. These findings suggest that high dietary levels of soy i...Continue Reading

Citations

May 11, 2005·Maturitas·Thomas B Clarkson, Susan E Appt
Dec 27, 2007·Journal of Medicinal Food·Won O SongSung G Lee
Jul 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tai L GuoRui P Chi
Oct 6, 2007·Menopause : the Journal of the North American Menopause Society·Irma H SupartoDondin Sajuthi
Jun 4, 2008·Menopause : the Journal of the North American Menopause Society·Charles E WoodJ Mark Cline
Mar 7, 2009·Menopause : the Journal of the North American Menopause Society·Charles E WoodJ Mark Cline
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Latanya M ScottJ Mark Cline
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles E WoodJ Mark Cline
Oct 29, 2008·The Journal of Steroid Biochemistry and Molecular Biology·L M ScottJ M Cline
Jul 3, 2007·Ageing Research Reviews·Wolfgang WuttkeDana Seidlová-Wuttke
Mar 27, 2009·American Journal of Primatology·J Mark Cline, Charles E Wood
Aug 6, 2005·The Journal of Nutritional Biochemistry·Renea R EasonRosalia C M Simmen
Dec 21, 2006·Nutrition and Cancer·Charles E WoodJ Mark Cline
Dec 1, 2008·Toxicologic Pathology·J Mark Cline, Charles E Wood
Sep 26, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Karl K RozmanDavid Umbach
Apr 20, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·J Mark Cline
Jan 21, 2006·Cancer Research·Charles E WoodJ Mark Cline

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