Breast cancer and exposure to tobacco smoke during potential windows of susceptibility

Cancer Causes & Control : CCC
Alexandra J WhiteDale P Sandler

Abstract

An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life. Sister study participants (n = 50,884) aged 35-74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they were breast cancer-free but had a sister with breast cancer. Participants completed questionnaires on smoking and environmental tobacco smoke (ETS) exposure. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for breast cancer risk. During follow-up (mean = 6.4 years), 1,843 invasive breast cancers were diagnosed. Neither active smoking nor adult ETS was associated with breast cancer risk. However, never smoking women exposed to ETS throughout their childhood had a 17% higher risk of breast cancer (95% CI 1.00-1.36) relative to those with no exposure. In utero ETS exposure was also associated with breast cancer (HR = 1.16, 95% CI 1.01-1.32) and the HR was most elevated for women born in earlier birth cohor...Continue Reading

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Citations

Sep 11, 2018·Epidemiology·Alexandra J WhiteDale P Sandler
Jan 18, 2020·JAMA Network Open·Jacob K KresovichJack A Taylor
Dec 19, 2019·Aging·Jacob K KresovichJack A Taylor
Jun 6, 2019·Breast Cancer Research and Treatment·John D MurphyKatie M O'Brien
Mar 2, 2021·International Journal of Epidemiology·Tianyi WangShelley S Tworoger
Feb 11, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anniina TastulaJouko Miettunen

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