PMID: 7543800May 1, 1995Paper

Breast cancer angiogenesis: a quantitative morphologic and Doppler imaging study

Annals of Surgical Oncology
W J LeeK M Chen

Abstract

Tumor growth and metastases require the development of new vessels (angiogenesis). Angiogenesis, assessed by microvessel count using immunocytochemical stain of endothelial cells, has been shown to predict metastases and correlate with early death. Recently developed color Doppler mapping can detect the "tumor flow signals" in breast cancer and help to distinguish it from benign lesions. The question is, does this tumor vascularization assessed by color Doppler mapping correlate with the angiogenesis assessed by immunocytochemistry? Eighty-four patients admitted for breast surgery were studied. The final diagnosis was made by pathology for 52 malignancies and 32 benign lesions. The color Doppler mapping of the breast lesion was made preoperatively. The following parameters were assessed: (a) vessel location (peripheral or central); (b) density of color Doppler signals; and (c) maximum systolic velocity. Tumor angiogenesis was assessed by microvessel count under light microscopy using the platelet/endothelial cell adhesion molecule antibodies (CD31) method. The correlation between maximum velocity and microvessel count of breast cancer was examined. The clinical significance of maximum flow velocity of breast cancer with various...Continue Reading

References

Jan 1, 1978·Ultrasound in Medicine & Biology·D N White, P R Cledgett
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Dec 1, 1990·Clinical Radiology·P D Britton, R A Coulden
Jul 1, 1990·Radiology·D O CosgroveH D Sinnett
Nov 1, 1990·Radiology·V P Jackson
Jan 1, 1990·Ultrasound in Medicine & Biology·D D AdlerD Quinn-Reid
Sep 1, 1988·Radiology·S G SchoenbergerA E Robinson
Apr 1, 1969·Cancer·F Feldman
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·P Shubik
Mar 1, 1983·Radiology·A P HarperV P Jackson
Jan 1, 1982·Ultrasound in Medicine & Biology·P N BurnsA J Webb
Feb 1, 1993·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·W Dock

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Citations

Mar 11, 1998·Breast Cancer Research and Treatment·C Peters-EnglA Obermair
May 23, 1998·Journal of Biomedical Materials Research·A A SharkawyW M Reichert
Jun 3, 2006·American Journal of Veterinary Research·Helena T NymanAnnemarie T Kristensen
Jan 1, 1996·Breast Cancer Research and Treatment·W J LeeK M Chen
Feb 7, 2019·The Breast Journal·Mariona VilagranVirtudes Gómez
Aug 21, 2002·Breast Cancer Research and Treatment·Sung-Won KimDong-Young Noh
Nov 7, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Wei Tse YangJenny Chang
Dec 24, 2011·AJR. American Journal of Roentgenology·Eleonora HorvathEduardo Soto
Mar 5, 1999·Breast Cancer Research and Treatment·I C Henderson, A J Patek

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