Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Frontiers of Medicine
Aixiu QiaoLi Fu

Abstract

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.

References

May 15, 1988·International Journal of Cancer. Journal International Du Cancer·A P SappinoG Gabbiani
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D A BronzertM E Lippman
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 12, 2000·Oncogene·Z M ShaoS H Barsky
May 29, 2002·Pathology International·Kazuki NabeshimaTetsuro Sameshima
Aug 2, 2003·International Immunopharmacology·Kousei TanakaMuneaki Abe
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KuperwasserRobert A Weinberg
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Mar 9, 2005·Cancer Research·Hippokratis KiarisAnastasios Kalofoutis
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Jun 24, 2006·The Journal of Clinical Investigation·Markus LoefflerRalph A Reisfeld
Nov 16, 2006·Cancer Biology & Therapy·Hikaru SugimotoRaghu Kalluri
Apr 10, 2007·The International Journal of Biochemistry & Cell Biology·Jennifer A Przybylo, Derek C Radisky
Jun 4, 2008·Cancer Research·Pravin J MishraDebabrata Banerjee
Aug 21, 2008·Human Molecular Genetics·George TrimisAthanasios G Papavassiliou
Sep 9, 2008·International Journal of Cancer. Journal International Du Cancer·Olivier De WeverMarc Bracke
Sep 18, 2008·British Journal of Cancer·S PotentaR Kalluri
Oct 15, 2008·The Journal of Pathology·F PonténM Uhlen
Dec 3, 2008·Cancer Research·Le JiangBenjamin Tycko
Mar 6, 2009·Nature Reviews. Cancer·Kornelia Polyak, Robert A Weinberg
May 2, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marius RaicaDomenico Ribatti
May 5, 2009·The American Journal of Pathology·Agnieszka K WitkiewiczMichael P Lisanti
May 19, 2009·Cell Cycle·Agnieszka K WitkiewiczMichael P Lisanti
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roopali RoyMarsha A Moses
Oct 23, 2009·Nature·Anthony J TrimboliGustavo Leone
Oct 28, 2009·Seminars in Cell & Developmental Biology·Lisa M ArendtCharlotte Kuperwasser
Dec 1, 2009·Seminars in Cell & Developmental Biology·Georgia Xouri, Sven Christian

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Citations

Sep 8, 2016·Microarrays·Giuseppe MerlinoVera Cappelletti
Jul 8, 2016·Archives of Pharmacal Research·Hyesol Lim, Aree Moon
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vivian LabovskyNorma Alejandra Chasseing
Aug 1, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martin WartenbergEva Karamitopoulou
Dec 17, 2016·Scientific Reports·Russell BainerMarsha Rich Rosner
Sep 13, 2018·The Journal of Pathology. Clinical Research·Yihong WangMurray B Resnick
Mar 8, 2019·International Journal of Cancer. Journal International Du Cancer·Sebastián GiulianelliClaudia Lanari
Mar 18, 2020·Journal of Clinical Medicine·Patricia Fernández-NogueiraNeus Carbó
Jul 4, 2018·BioMed Research International·Angelica AvaglianoAlessandro Arcucci
Jul 13, 2018·International Journal of Molecular Sciences·Ernestina M De FrancescoAnna Maria Musti
Mar 9, 2019·Anti-cancer Agents in Medicinal Chemistry·Pritam N DubeSantosh N Mokale
Dec 17, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Hector Hernandez-VargasRobert Dante
Jan 6, 2021·Journal of Mammary Gland Biology and Neoplasia·María Belén GiorelloNorma Alejandra Chasseing
Jul 3, 2021·Cancers·Patricia Fernández-NogueiraPaloma Bragado

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